B0A49_10705 protein (Cryomyces minteri) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

B0A49_10705

Uncharacterized protein. (469 aa)

Predicted Functional Partners:

B0A49_11805

0.973

B0A49_11804

0.973

B0A49_11493

0.973

B0A49_10538

0.973

B0A49_06325

0.973

B0A49_02759

0.973

B0A49_00792

0.973

B0A49_01658

0.973

B0A49_02858

0.943

B0A49_06106

0.935

Your Current Organism:

Cryomyces minteri

NCBI taxonomy Id: 331657
Other names: C. minteri, CBS 116302, CBS 116302 (ex-type); CCFEE 5187, CCFEE 5187

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A49_00792	B0A49_02858	A0A4U0XJX5	A0A4U0XCF4	Uncharacterized protein.	Uncharacterized protein.	0.916
B0A49_00792	B0A49_06106	A0A4U0XJX5	A0A4V5NEI8	Uncharacterized protein.	Uncharacterized protein.	0.710
B0A49_00792	B0A49_10705	A0A4U0XJX5	A0A4U0WGK9	Uncharacterized protein.	Uncharacterized protein.	0.973
B0A49_01658	B0A49_02858	A0A4U0XTV8	A0A4U0XCF4	Fe2OG dioxygenase domain-containing protein.	Uncharacterized protein.	0.916
B0A49_01658	B0A49_06106	A0A4U0XTV8	A0A4V5NEI8	Fe2OG dioxygenase domain-containing protein.	Uncharacterized protein.	0.710
B0A49_01658	B0A49_10705	A0A4U0XTV8	A0A4U0WGK9	Fe2OG dioxygenase domain-containing protein.	Uncharacterized protein.	0.973
B0A49_02759	B0A49_02858	A0A4U0XAQ5	A0A4U0XCF4	Histone H3-like centromeric protein hH3v.	Uncharacterized protein.	0.983
B0A49_02759	B0A49_06106	A0A4U0XAQ5	A0A4V5NEI8	Histone H3-like centromeric protein hH3v.	Uncharacterized protein.	0.756
B0A49_02759	B0A49_10705	A0A4U0XAQ5	A0A4U0WGK9	Histone H3-like centromeric protein hH3v.	Uncharacterized protein.	0.973
B0A49_02858	B0A49_00792	A0A4U0XCF4	A0A4U0XJX5	Uncharacterized protein.	Uncharacterized protein.	0.916
B0A49_02858	B0A49_01658	A0A4U0XCF4	A0A4U0XTV8	Uncharacterized protein.	Fe2OG dioxygenase domain-containing protein.	0.916
B0A49_02858	B0A49_02759	A0A4U0XCF4	A0A4U0XAQ5	Uncharacterized protein.	Histone H3-like centromeric protein hH3v.	0.983
B0A49_02858	B0A49_06106	A0A4U0XCF4	A0A4V5NEI8	Uncharacterized protein.	Uncharacterized protein.	0.992
B0A49_02858	B0A49_06325	A0A4U0XCF4	A0A4U0WQ74	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.983
B0A49_02858	B0A49_10538	A0A4U0XCF4	A0A4U0WHN5	Uncharacterized protein.	DUF2236 domain-containing protein.	0.916
B0A49_02858	B0A49_10705	A0A4U0XCF4	A0A4U0WGK9	Uncharacterized protein.	Uncharacterized protein.	0.943
B0A49_02858	B0A49_11493	A0A4U0XCF4	A0A4U0W699	Uncharacterized protein.	Histone H3-like centromeric protein hH3v.	0.983
B0A49_02858	B0A49_11804	A0A4U0XCF4	A0A4U0VL15	Uncharacterized protein.	Uncharacterized protein.	0.916
B0A49_02858	B0A49_11805	A0A4U0XCF4	A0A4U0VKN8	Uncharacterized protein.	DUF2236 domain-containing protein.	0.916
B0A49_06106	B0A49_00792	A0A4V5NEI8	A0A4U0XJX5	Uncharacterized protein.	Uncharacterized protein.	0.710

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.867

expected number of edges:

10

PPI enrichment p-value:

0.0092

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006744

Ubiquinone biosynthetic process

6 of 23

2.57

5.31

4.10e-11

GO:0042180

Cellular ketone metabolic process

7 of 71

2.14

4.66

4.10e-11

GO:0044283

Small molecule biosynthetic process

9 of 458

1.44

2.47

5.09e-10

GO:0032259

Methylation

6 of 183

1.67

2.41

6.03e-07

GO:0006568

Tryptophan metabolic process

3 of 13

2.51

2.34

4.14e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004395

Hexaprenyldihydroxybenzoate methyltransferase activity

6 of 6

3.15

7.26

3.93e-14

GO:0008689

3-demethylubiquinone-9 3-O-methyltransferase activity

5 of 5

3.15

6.0

9.23e-12

GO:0008425

2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity

5 of 7

3.0

5.8

1.74e-11

GO:0004834

Tryptophan synthase activity

2 of 3

2.97

1.75

0.00068

GO:0016740

Transferase activity

7 of 1615

0.79

0.59

0.0039

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031314

Extrinsic component of mitochondrial inner membrane

5 of 22

2.51

4.31

4.12e-09

GO:0019898

Extrinsic component of membrane

6 of 97

1.94

3.39

1.38e-08

GO:0005743

Mitochondrial inner membrane

6 of 358

1.37

1.62

1.39e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15336

Ubiquinol biosynthesis, and ABC1 atypical kinase-like domain

6 of 26

2.51

5.34

2.57e-11

CL:15180

Mixed, incl. Tryptophan catabolism, and Ubiquinol biosynthesis

8 of 104

2.04

4.81

2.22e-12

CL:15339

Ubiquinone metabolic process, and ABC1 atypical kinase-like domain

5 of 20

2.55

4.44

2.60e-09

CL:15342

Ubiquinone biosynthesis, and ABC1 atypical kinase-like domain

4 of 15

2.58

3.43

3.16e-07

CL:13512

Tryptophan biosynthetic process

2 of 5

2.75

1.29

0.0046

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00130

Ubiquinone and other terpenoid-quinone biosynthesis

7 of 59

2.22

5.44

8.78e-13

map00400

Phenylalanine, tyrosine and tryptophan biosynthesis

2 of 25

2.05

1.17

0.0059

map01110

Biosynthesis of secondary metabolites

6 of 1057

0.9

0.72

0.0017

map01100

Metabolic pathways

11 of 3257

0.68

0.64

2.65e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2142789

Ubiquinol biosynthesis

8 of 22

2.71

8.54

1.10e-17

MAP-8978934

Metabolism of cofactors

8 of 40

2.45

7.31

3.54e-16

MAP-196854

Metabolism of vitamins and cofactors

8 of 220

1.71

3.41

9.71e-11

MAP-1430728

Metabolism

9 of 2234

0.75

0.65

0.00027

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

7 of 971

1.01

0.85

0.0011

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0489

Methyltransferase

5 of 140

1.7

2.14

7.82e-06

KW-0822

Tryptophan biosynthesis

2 of 3

2.97

1.77

0.00061

KW-0663

Pyridoxal phosphate

3 of 58

1.86

1.51

0.00083

KW-0831

Ubiquinone biosynthesis

2 of 9

2.5

1.5

0.0017

KW-0999

Mitochondrion inner membrane

2 of 57

1.69

0.78

0.0291

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00290

Tryptophan synthase alpha chain

2 of 2

3.15

1.31

0.0044

PF13847

Methyltransferase domain

2 of 11

2.41

0.85

0.0282

PF00291

Pyridoxal-phosphate dependent enzyme

2 of 14

2.3

0.84

0.0289

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029063

S-adenosyl-L-methionine-dependent methyltransferase superfamily

5 of 167

1.63

1.53

0.00032

IPR023026

Tryptophan synthase beta chain/beta chain-like

2 of 3

2.97

1.22

0.0063

IPR018204

Tryptophan synthase, alpha chain, active site

2 of 2

3.15

1.22

0.0063

IPR006654

Tryptophan synthase, beta chain

2 of 3

2.97

1.22

0.0063

IPR006653

Tryptophan synthase, beta chain, conserved site

2 of 3

2.97

1.22

0.0063

(more ...)

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