B0A49_11125 protein (Cryomyces minteri) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

B0A49_11125

Uncharacterized protein. (1182 aa)

Predicted Functional Partners:

B0A49_05945

0.922

B0A49_09080

0.916

B0A49_08330

0.895

B0A49_07770

0.895

B0A49_06281

0.895

B0A49_09329

0.892

B0A49_06160

0.892

B0A49_11360

0.886

B0A49_08080

0.886

B0A49_12789

0.879

Your Current Organism:

Cryomyces minteri

NCBI taxonomy Id: 331657
Other names: C. minteri, CBS 116302, CBS 116302 (ex-type); CCFEE 5187, CCFEE 5187

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A49_05945	B0A49_06281	A0A4U0X1T4	A0A4U0WMC8	Adenylyl cyclase-associated protein; Belongs to the CAP family.	Uncharacterized protein.	0.921
B0A49_05945	B0A49_07770	A0A4U0X1T4	A0A4U0WIA5	Adenylyl cyclase-associated protein; Belongs to the CAP family.	Uncharacterized protein.	0.921
B0A49_05945	B0A49_08080	A0A4U0X1T4	A0A4U0WYF0	Adenylyl cyclase-associated protein; Belongs to the CAP family.	Ras-like protein.	0.464
B0A49_05945	B0A49_08330	A0A4U0X1T4	A0A4U0WGQ2	Adenylyl cyclase-associated protein; Belongs to the CAP family.	Uncharacterized protein.	0.921
B0A49_05945	B0A49_11125	A0A4U0X1T4	A0A4U0WIR2	Adenylyl cyclase-associated protein; Belongs to the CAP family.	Uncharacterized protein.	0.922
B0A49_05945	B0A49_11360	A0A4U0X1T4	A0A4U0VL12	Adenylyl cyclase-associated protein; Belongs to the CAP family.	Ras-like protein.	0.464
B0A49_06160	B0A49_08080	A0A4U0WZX4	A0A4U0WYF0	Uncharacterized protein.	Ras-like protein.	0.490
B0A49_06160	B0A49_09329	A0A4U0WZX4	A0A4U0WTX5	Uncharacterized protein.	Uncharacterized protein.	0.876
B0A49_06160	B0A49_11125	A0A4U0WZX4	A0A4U0WIR2	Uncharacterized protein.	Uncharacterized protein.	0.892
B0A49_06160	B0A49_11360	A0A4U0WZX4	A0A4U0VL12	Uncharacterized protein.	Ras-like protein.	0.490
B0A49_06281	B0A49_05945	A0A4U0WMC8	A0A4U0X1T4	Uncharacterized protein.	Adenylyl cyclase-associated protein; Belongs to the CAP family.	0.921
B0A49_06281	B0A49_07770	A0A4U0WMC8	A0A4U0WIA5	Uncharacterized protein.	Uncharacterized protein.	0.958
B0A49_06281	B0A49_08080	A0A4U0WMC8	A0A4U0WYF0	Uncharacterized protein.	Ras-like protein.	0.578
B0A49_06281	B0A49_08330	A0A4U0WMC8	A0A4U0WGQ2	Uncharacterized protein.	Uncharacterized protein.	0.958
B0A49_06281	B0A49_09080	A0A4U0WMC8	A0A4U0WLX8	Uncharacterized protein.	Phosphodiesterase.	0.495
B0A49_06281	B0A49_11125	A0A4U0WMC8	A0A4U0WIR2	Uncharacterized protein.	Uncharacterized protein.	0.895
B0A49_06281	B0A49_11360	A0A4U0WMC8	A0A4U0VL12	Uncharacterized protein.	Ras-like protein.	0.578
B0A49_07770	B0A49_05945	A0A4U0WIA5	A0A4U0X1T4	Uncharacterized protein.	Adenylyl cyclase-associated protein; Belongs to the CAP family.	0.921
B0A49_07770	B0A49_06281	A0A4U0WIA5	A0A4U0WMC8	Uncharacterized protein.	Uncharacterized protein.	0.958
B0A49_07770	B0A49_08080	A0A4U0WIA5	A0A4U0WYF0	Uncharacterized protein.	Ras-like protein.	0.578

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.851

expected number of edges:

10

PPI enrichment p-value:

3.1e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043953

Protein transport by the Tat complex

6 of 6

2.4

4.53

8.38e-10

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008320

Protein transmembrane transporter activity

6 of 14

2.03

3.48

1.93e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033281

TAT protein transport complex

6 of 6

2.4

4.97

8.51e-11

GO:0005887

Integral component of plasma membrane

6 of 55

1.44

1.93

1.18e-06

GO:0032991

Protein-containing complex

7 of 219

0.9

0.84

0.00011

GO:0071944

Cell periphery

9 of 600

0.57

0.47

0.00074

GO:0005886

Plasma membrane

8 of 507

0.6

0.46

0.0021

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28848502

(2017) In silico Analyses of Subtype Specific HIV-1 Tat-TAR RNA Interaction Reveals the Structural Determinants for Viral Activity.

4 of 4

2.4

2.93

2.31e-06

PMID:24465566

(2014) Molecular and genetic characterization of natural HIV-1 Tat Exon-1 variants from North India and their functional implications.

4 of 4

2.4

2.93

2.31e-06

PMID:26880113

(2016) Inferences from tip-calibrated phylogenies: a review and a practical guide.

2 of 2

2.4

1.17

0.0070

PMID:24236045

(2013) Diversity and evolution of bacterial twin arginine translocase protein, TatC, reveals a protein secretion system that is evolving to fit its environmental niche.

2 of 7

1.85

0.79

0.0313

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4521

TAT protein transport complex

6 of 6

2.4

4.78

2.20e-10

CL:4509

TAT protein transport complex, and Copper ion binding

7 of 12

2.16

4.69

4.33e-11

CL:4352

Mixed, incl. Efflux transmembrane transporter activity, and RND efflux pump, membrane fusion protein

8 of 94

1.33

1.89

8.44e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

mfa03060

Protein export

6 of 19

1.9

3.32

1.23e-08

mfa03070

Bacterial secretion system

6 of 33

1.66

2.59

1.10e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0033281

TAT protein transport complex

6 of 6

2.4

4.83

1.70e-10

GOCC:0005886

Plasma membrane

7 of 353

0.7

0.49

0.0077

GOCC:0032991

Protein-containing complex

7 of 443

0.6

0.38

0.0261

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

6 of 14

2.03

3.66

6.34e-09

KW-0997

Cell inner membrane

7 of 108

1.21

1.44

3.85e-06

KW-1133

Transmembrane helix

8 of 566

0.55

0.39

0.0112

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00902

Sec-independent protein translocase protein (TatC)

2 of 2

2.4

0.75

0.0425

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003369

Sec-independent protein translocase protein TatA/B/E

4 of 4

2.4

2.59

1.13e-05

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