B0A49_06146 protein (Cryomyces minteri) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

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[Homology]

Score

B0A49_06146

Iwr1 domain-containing protein. (490 aa)

Predicted Functional Partners:

B0A49_11252

0.879

B0A49_01165

0.815

B0A49_07129

0.799

B0A49_08414

0.754

B0A49_10986

0.754

B0A49_09327

0.717

B0A49_12810

0.717

B0A49_00976

0.696

B0A49_00315

0.696

B0A49_05131

0.630

Your Current Organism:

Cryomyces minteri

NCBI taxonomy Id: 331657
Other names: C. minteri, CBS 116302, CBS 116302 (ex-type); CCFEE 5187, CCFEE 5187

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B0A49_00315	B0A49_01165	A0A4U0XXW7	A0A4U0XDA9	TFIIS-type domain-containing protein.	RNA_pol_L_2 domain-containing protein.	0.997
B0A49_00315	B0A49_05131	A0A4U0XXW7	A0A4U0WYQ6	TFIIS-type domain-containing protein.	RPOLD domain-containing protein.	0.900
B0A49_00315	B0A49_06146	A0A4U0XXW7	A0A4U0WYB4	TFIIS-type domain-containing protein.	Iwr1 domain-containing protein.	0.696
B0A49_00315	B0A49_07129	A0A4U0XXW7	A0A4U0X134	TFIIS-type domain-containing protein.	RPOL4c domain-containing protein.	0.993
B0A49_00315	B0A49_08414	A0A4U0XXW7	A0A4U0W656	TFIIS-type domain-containing protein.	Uncharacterized protein.	0.987
B0A49_00315	B0A49_09327	A0A4U0XXW7	A0A4U0WJL9	TFIIS-type domain-containing protein.	DNA-directed RNA polymerase II subunit RPB2.	0.985
B0A49_00315	B0A49_10986	A0A4U0XXW7	A0A4U0WJ50	TFIIS-type domain-containing protein.	Uncharacterized protein.	0.987
B0A49_00315	B0A49_11252	A0A4U0XXW7	A0A4U0VKZ6	TFIIS-type domain-containing protein.	RPOLD domain-containing protein.	0.993
B0A49_00315	B0A49_12810	A0A4U0XXW7	A0A4U0WW05	TFIIS-type domain-containing protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.985
B0A49_00976	B0A49_01165	A0A4U0XLU8	A0A4U0XDA9	TFIIS-type domain-containing protein.	RNA_pol_L_2 domain-containing protein.	0.997
B0A49_00976	B0A49_05131	A0A4U0XLU8	A0A4U0WYQ6	TFIIS-type domain-containing protein.	RPOLD domain-containing protein.	0.900
B0A49_00976	B0A49_06146	A0A4U0XLU8	A0A4U0WYB4	TFIIS-type domain-containing protein.	Iwr1 domain-containing protein.	0.696
B0A49_00976	B0A49_07129	A0A4U0XLU8	A0A4U0X134	TFIIS-type domain-containing protein.	RPOL4c domain-containing protein.	0.993
B0A49_00976	B0A49_08414	A0A4U0XLU8	A0A4U0W656	TFIIS-type domain-containing protein.	Uncharacterized protein.	0.987
B0A49_00976	B0A49_09327	A0A4U0XLU8	A0A4U0WJL9	TFIIS-type domain-containing protein.	DNA-directed RNA polymerase II subunit RPB2.	0.985
B0A49_00976	B0A49_10986	A0A4U0XLU8	A0A4U0WJ50	TFIIS-type domain-containing protein.	Uncharacterized protein.	0.987
B0A49_00976	B0A49_11252	A0A4U0XLU8	A0A4U0VKZ6	TFIIS-type domain-containing protein.	RPOLD domain-containing protein.	0.993
B0A49_00976	B0A49_12810	A0A4U0XLU8	A0A4U0WW05	TFIIS-type domain-containing protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.985
B0A49_01165	B0A49_00315	A0A4U0XDA9	A0A4U0XXW7	RNA_pol_L_2 domain-containing protein.	TFIIS-type domain-containing protein.	0.997
B0A49_01165	B0A49_00976	A0A4U0XDA9	A0A4U0XLU8	RNA_pol_L_2 domain-containing protein.	TFIIS-type domain-containing protein.	0.997

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Network Stats

number of nodes:

11

number of edges:

45

average node degree:

8.18

avg. local clustering coefficient:

0.761

expected number of edges:

12

PPI enrichment p-value:

9.59e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018105

Peptidyl-serine phosphorylation

3 of 90

1.9

1.1

0.0072

GO:0071218

Cellular response to misfolded protein

2 of 19

2.4

0.99

0.0155

GO:0051247

Positive regulation of protein metabolic process

3 of 135

1.73

0.96

0.0118

GO:0006515

Protein quality control for misfolded or incompletely synthesized proteins

2 of 43

2.05

0.73

0.0434

GO:0045862

Positive regulation of proteolysis

2 of 57

1.93

0.71

0.0450

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004842

Ubiquitin-protein transferase activity

4 of 422

1.36

0.82

0.0137

GO:0061630

Ubiquitin protein ligase activity

3 of 225

1.51

0.74

0.0291

GO:0140096

Catalytic activity, acting on a protein

9 of 3324

0.81

0.69

0.00053

GO:0016740

Transferase activity

10 of 4634

0.71

0.6

0.00053

GO:0016301

Kinase activity

6 of 1874

0.89

0.56

0.0178

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005776

Autophagosome

2 of 22

2.34

0.79

0.0353

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13820

Mixed, incl. Ubiquitin conjugating enzyme activity, and Ubiquitin homologues

3 of 84

1.93

0.83

0.0263

CL:20418

Mixed, incl. MAP kinase activity, and Rho (Ras homology) subfamily of Ras-like small GTPases

2 of 21

2.36

0.82

0.0312

CL:35943

Autophagy - other

2 of 23

2.32

0.82

0.0317

CL:13925

Ubiquitin conjugating enzyme activity, and Lipid desaturase domain

2 of 27

2.25

0.78

0.0375

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005776

Autophagosome

2 of 17

2.45

0.81

0.0341

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045202

CHIP , U-box domain

2 of 2

3.38

1.25

0.0056

IPR045200

E3 ubiquitin-protein ligase CHIP

2 of 2

3.38

1.25

0.0056

IPR000433

Zinc finger, ZZ-type

2 of 8

2.78

1.03

0.0139

IPR043145

Zinc finger, ZZ-type superfamily

2 of 9

2.73

1.02

0.0139

IPR027370

Zinc finger, RING-type, eukaryotic

2 of 12

2.6

0.98

0.0168

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00028

Tetratricopeptide repeats

3 of 67

2.03

1.47

0.0014

SM00291

Zinc-binding domain, present in Dystrophin, CREB-binding protein.

2 of 15

2.51

1.25

0.0052

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