node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B0A49_00449 | B0A49_01829 | A0A4U0XV28 | A0A4U0XRN3 | Guanylate kinase-like domain-containing protein. | Pribosyltran domain-containing protein. | 0.937 |
B0A49_00449 | B0A49_03139 | A0A4U0XV28 | A0A4U0XT19 | Guanylate kinase-like domain-containing protein. | Uncharacterized protein. | 0.819 |
B0A49_00449 | B0A49_04867 | A0A4U0XV28 | A0A4V5NDP1 | Guanylate kinase-like domain-containing protein. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.890 |
B0A49_00449 | B0A49_07612 | A0A4U0XV28 | A0A4U0WSV9 | Guanylate kinase-like domain-containing protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.855 |
B0A49_00449 | B0A49_10105 | A0A4U0XV28 | A0A4U0WPE0 | Guanylate kinase-like domain-containing protein. | Inosine-5'-monophosphate dehydrogenase. | 0.855 |
B0A49_01829 | B0A49_00449 | A0A4U0XRN3 | A0A4U0XV28 | Pribosyltran domain-containing protein. | Guanylate kinase-like domain-containing protein. | 0.937 |
B0A49_01829 | B0A49_03052 | A0A4U0XRN3 | A0A4U0WYI6 | Pribosyltran domain-containing protein. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.709 |
B0A49_01829 | B0A49_03139 | A0A4U0XRN3 | A0A4U0XT19 | Pribosyltran domain-containing protein. | Uncharacterized protein. | 0.884 |
B0A49_01829 | B0A49_03545 | A0A4U0XRN3 | A0A4U0XKA7 | Pribosyltran domain-containing protein. | Uncharacterized protein. | 0.697 |
B0A49_01829 | B0A49_04295 | A0A4U0XRN3 | A0A4U0X6U8 | Pribosyltran domain-containing protein. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.709 |
B0A49_01829 | B0A49_04536 | A0A4U0XRN3 | A0A4V5NFP2 | Pribosyltran domain-containing protein. | Uncharacterized protein. | 0.936 |
B0A49_01829 | B0A49_04867 | A0A4U0XRN3 | A0A4V5NDP1 | Pribosyltran domain-containing protein. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.888 |
B0A49_01829 | B0A49_04968 | A0A4U0XRN3 | A0A4U0XBN9 | Pribosyltran domain-containing protein. | PNP_UDP_1 domain-containing protein. | 0.896 |
B0A49_01829 | B0A49_07612 | A0A4U0XRN3 | A0A4U0WSV9 | Pribosyltran domain-containing protein. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.902 |
B0A49_01829 | B0A49_10105 | A0A4U0XRN3 | A0A4U0WPE0 | Pribosyltran domain-containing protein. | Inosine-5'-monophosphate dehydrogenase. | 0.902 |
B0A49_03052 | B0A49_01829 | A0A4U0WYI6 | A0A4U0XRN3 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Pribosyltran domain-containing protein. | 0.709 |
B0A49_03052 | B0A49_03139 | A0A4U0WYI6 | A0A4U0XT19 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Uncharacterized protein. | 0.844 |
B0A49_03052 | B0A49_04867 | A0A4U0WYI6 | A0A4V5NDP1 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.910 |
B0A49_03052 | B0A49_04968 | A0A4U0WYI6 | A0A4U0XBN9 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | PNP_UDP_1 domain-containing protein. | 0.402 |
B0A49_03052 | B0A49_07612 | A0A4U0WYI6 | A0A4U0WSV9 | Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. | 0.961 |