node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACE03936.1 | ACE04719.1 | Cphamn1_0993 | Cphamn1_1801 | KEGG: lch:Lcho_1136 hypothetical protein. | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | 0.486 |
ACE03936.1 | dnaK | Cphamn1_0993 | Cphamn1_1707 | KEGG: lch:Lcho_1136 hypothetical protein. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.931 |
ACE03936.1 | groL | Cphamn1_0993 | Cphamn1_0783 | KEGG: lch:Lcho_1136 hypothetical protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.713 |
ACE03936.1 | groS | Cphamn1_0993 | Cphamn1_0782 | KEGG: lch:Lcho_1136 hypothetical protein. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.486 |
ACE03936.1 | grpE | Cphamn1_0993 | Cphamn1_0853 | KEGG: lch:Lcho_1136 hypothetical protein. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.799 |
ACE03936.1 | hrcA | Cphamn1_0993 | Cphamn1_0852 | KEGG: lch:Lcho_1136 hypothetical protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.677 |
ACE03936.1 | hslU | Cphamn1_0993 | Cphamn1_1438 | KEGG: lch:Lcho_1136 hypothetical protein. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.611 |
ACE03936.1 | hslV | Cphamn1_0993 | Cphamn1_1439 | KEGG: lch:Lcho_1136 hypothetical protein. | 20S proteasome A and B subunits; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.438 |
ACE03936.1 | htpG | Cphamn1_0993 | Cphamn1_1195 | KEGG: lch:Lcho_1136 hypothetical protein. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.909 |
ACE04719.1 | ACE03936.1 | Cphamn1_1801 | Cphamn1_0993 | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | KEGG: lch:Lcho_1136 hypothetical protein. | 0.486 |
ACE04719.1 | dnaJ | Cphamn1_1801 | Cphamn1_0854 | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.662 |
ACE04719.1 | dnaK | Cphamn1_1801 | Cphamn1_1707 | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.772 |
ACE04719.1 | groL | Cphamn1_1801 | Cphamn1_0783 | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.864 |
ACE04719.1 | grpE | Cphamn1_1801 | Cphamn1_0853 | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.745 |
ACE04719.1 | hslU | Cphamn1_1801 | Cphamn1_1438 | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.669 |
ACE04719.1 | hslV | Cphamn1_1801 | Cphamn1_1439 | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | 20S proteasome A and B subunits; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.622 |
ACE04719.1 | htpG | Cphamn1_1801 | Cphamn1_1195 | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity. | 0.693 |
dnaJ | ACE04719.1 | Cphamn1_0854 | Cphamn1_1801 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | PFAM: chaperonin Cpn10; KEGG: cch:Cag_1167 chaperonin, 10 kDa. | 0.662 |
dnaJ | dnaK | Cphamn1_0854 | Cphamn1_1707 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.997 |
dnaJ | groL | Cphamn1_0854 | Cphamn1_0783 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.844 |