| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACE03068.1 | lysA | Cphamn1_0085 | Cphamn1_0976 | PFAM: NAD(P)H dehydrogenase (quinone); KEGG: gvi:glr1342 probable NADP(H) oxidoreductase. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.765 |
| ACE04349.1 | ACE04568.1 | Cphamn1_1421 | Cphamn1_1649 | KEGG: aoe:Clos_0418 lysine 2,3-aminomutase YodO family protein; TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein. | Lysine 2,3-aminomutase YodO family protein; KEGG: plt:Plut_1576 protein of unknown function DUF160; TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein. | 0.913 |
| ACE04349.1 | lysA | Cphamn1_1421 | Cphamn1_0976 | KEGG: aoe:Clos_0418 lysine 2,3-aminomutase YodO family protein; TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.800 |
| ACE04568.1 | ACE04349.1 | Cphamn1_1649 | Cphamn1_1421 | Lysine 2,3-aminomutase YodO family protein; KEGG: plt:Plut_1576 protein of unknown function DUF160; TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein. | KEGG: aoe:Clos_0418 lysine 2,3-aminomutase YodO family protein; TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein. | 0.913 |
| ACE04568.1 | lysA | Cphamn1_1649 | Cphamn1_0976 | Lysine 2,3-aminomutase YodO family protein; KEGG: plt:Plut_1576 protein of unknown function DUF160; TIGRFAM: lysine 2,3-aminomutase YodO family protein; PFAM: Radical SAM domain protein. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.800 |
| ACE05002.1 | ACE05340.1 | Cphamn1_2093 | Cphamn1_2445 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | KEGG: cch:Cag_2023 aspartate kinase region; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. | 0.510 |
| ACE05002.1 | asd | Cphamn1_2093 | Cphamn1_2183 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.477 |
| ACE05002.1 | dapF | Cphamn1_2093 | Cphamn1_0304 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.453 |
| ACE05002.1 | lysA | Cphamn1_2093 | Cphamn1_0976 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.567 |
| ACE05340.1 | ACE05002.1 | Cphamn1_2445 | Cphamn1_2093 | KEGG: cch:Cag_2023 aspartate kinase region; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.510 |
| ACE05340.1 | asd | Cphamn1_2445 | Cphamn1_2183 | KEGG: cch:Cag_2023 aspartate kinase region; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | 0.970 |
| ACE05340.1 | dapA | Cphamn1_2445 | Cphamn1_0593 | KEGG: cch:Cag_2023 aspartate kinase region; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.550 |
| ACE05340.1 | dapB | Cphamn1_2445 | Cphamn1_2084 | KEGG: cch:Cag_2023 aspartate kinase region; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. | 0.524 |
| ACE05340.1 | lysA | Cphamn1_2445 | Cphamn1_0976 | KEGG: cch:Cag_2023 aspartate kinase region; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.929 |
| asd | ACE05002.1 | Cphamn1_2183 | Cphamn1_2093 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.477 |
| asd | ACE05340.1 | Cphamn1_2183 | Cphamn1_2445 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | KEGG: cch:Cag_2023 aspartate kinase region; TIGRFAM: aspartate kinase; PFAM: aspartate/glutamate/uridylate kinase; amino acid-binding ACT domain protein; Belongs to the aspartokinase family. | 0.970 |
| asd | dapA | Cphamn1_2183 | Cphamn1_0593 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.965 |
| asd | dapB | Cphamn1_2183 | Cphamn1_2084 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. | 0.558 |
| asd | dapF | Cphamn1_2183 | Cphamn1_0304 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.566 |
| asd | lysA | Cphamn1_2183 | Cphamn1_0976 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.606 |