| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACE04493.1 | ACE04543.1 | Cphamn1_1570 | Cphamn1_1623 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: gme:Gmet_1630 haloacid dehalogenase-like hydrolase. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.444 |
| ACE04493.1 | ACE04544.1 | Cphamn1_1570 | Cphamn1_1624 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: gme:Gmet_1630 haloacid dehalogenase-like hydrolase. | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: cte:CT0746 deoxycytidylate deaminase, putative. | 0.911 |
| ACE04493.1 | ACE04948.1 | Cphamn1_1570 | Cphamn1_2038 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: gme:Gmet_1630 haloacid dehalogenase-like hydrolase. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.901 |
| ACE04493.1 | dut | Cphamn1_1570 | Cphamn1_0943 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: gme:Gmet_1630 haloacid dehalogenase-like hydrolase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
| ACE04493.1 | surE | Cphamn1_1570 | Cphamn1_2041 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: gme:Gmet_1630 haloacid dehalogenase-like hydrolase. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.906 |
| ACE04493.1 | tmk | Cphamn1_1570 | Cphamn1_1029 | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: gme:Gmet_1630 haloacid dehalogenase-like hydrolase. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.902 |
| ACE04543.1 | ACE04493.1 | Cphamn1_1623 | Cphamn1_1570 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: gme:Gmet_1630 haloacid dehalogenase-like hydrolase. | 0.444 |
| ACE04543.1 | ACE04544.1 | Cphamn1_1623 | Cphamn1_1624 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: cte:CT0746 deoxycytidylate deaminase, putative. | 0.815 |
| ACE04543.1 | ACE04545.1 | Cphamn1_1623 | Cphamn1_1625 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | PFAM: protein of unknown function DUF814; KEGG: cte:CT0745 fibronectin-binding protein, putative. | 0.618 |
| ACE04543.1 | ACE04546.1 | Cphamn1_1623 | Cphamn1_1626 | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | PFAM: thioesterase superfamily protein; KEGG: cch:Cag_0621 cytosolic long-chain acyl-CoA thioester hydrolase family protein. | 0.571 |
| ACE04544.1 | ACE04493.1 | Cphamn1_1624 | Cphamn1_1570 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: cte:CT0746 deoxycytidylate deaminase, putative. | TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: gme:Gmet_1630 haloacid dehalogenase-like hydrolase. | 0.911 |
| ACE04544.1 | ACE04543.1 | Cphamn1_1624 | Cphamn1_1623 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: cte:CT0746 deoxycytidylate deaminase, putative. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.815 |
| ACE04544.1 | ACE04545.1 | Cphamn1_1624 | Cphamn1_1625 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: cte:CT0746 deoxycytidylate deaminase, putative. | PFAM: protein of unknown function DUF814; KEGG: cte:CT0745 fibronectin-binding protein, putative. | 0.557 |
| ACE04544.1 | ACE04546.1 | Cphamn1_1624 | Cphamn1_1626 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: cte:CT0746 deoxycytidylate deaminase, putative. | PFAM: thioesterase superfamily protein; KEGG: cch:Cag_0621 cytosolic long-chain acyl-CoA thioester hydrolase family protein. | 0.529 |
| ACE04544.1 | ACE04948.1 | Cphamn1_1624 | Cphamn1_2038 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: cte:CT0746 deoxycytidylate deaminase, putative. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.909 |
| ACE04544.1 | dut | Cphamn1_1624 | Cphamn1_0943 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: cte:CT0746 deoxycytidylate deaminase, putative. | Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.935 |
| ACE04544.1 | surE | Cphamn1_1624 | Cphamn1_2041 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: cte:CT0746 deoxycytidylate deaminase, putative. | Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
| ACE04544.1 | tmk | Cphamn1_1624 | Cphamn1_1029 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: cte:CT0746 deoxycytidylate deaminase, putative. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.922 |
| ACE04545.1 | ACE04543.1 | Cphamn1_1625 | Cphamn1_1623 | PFAM: protein of unknown function DUF814; KEGG: cte:CT0745 fibronectin-binding protein, putative. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.618 |
| ACE04545.1 | ACE04544.1 | Cphamn1_1625 | Cphamn1_1624 | PFAM: protein of unknown function DUF814; KEGG: cte:CT0745 fibronectin-binding protein, putative. | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: cte:CT0746 deoxycytidylate deaminase, putative. | 0.557 |