STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACT1Actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells (376 aa)    
Predicted Functional Partners:
TFB3
RNA polymerase II transcription factor B subunit 3; Acts as component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH as CTD kinase activity and DNA-dependent ATPase activity, and is essential for polymerase II transcription (By similarity)
   
   0.999
AAS51582
ADL337Wp
   
 
 0.992
AAS54775
AGR285Wp
    
 
 0.986
AAS51060
Profilin; Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations
   
 
 0.982
AAS50808
ABR038Cp
    
 
 0.979
AAS54558
AGR069Cp
   
 
 0.975
COF1
Cofilin; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with [...]
   
 
 0.974
AAS53432
Adenylyl cyclase-associated protein; Belongs to the CAP family
   
 
 0.971
AAS51294
ACR068Wp; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family
   
 
 0.965
AAS50876
ABR105Cp
   
 
 0.952
Your Current Organism:
Eremothecium gossypii
NCBI taxonomy Id: 33169
Other names: Ashbya gossypii, E. gossypii, Eremothecium gossypii, Eremothecium gossypii (Ashby & Nowell) Kurtzman, Nematospora gossypii
Server load: low (9%) [HD]