STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EDP62263.1COG0473 Isocitrate/isopropylmalate dehydrogenase. (378 aa)    
Predicted Functional Partners:
cobU
Adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.922
leuC
3-isopropylmalate dehydratase large subunit region; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.907
leuD-3
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.887
EDP64283.1
COG0067 Glutamate synthase domain 1.
  
 
 0.885
leuD
Isopropylmalate isomerase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.870
EDP65673.1
COG0440 Acetolactate synthase, small (regulatory) subunit.
  
 0.808
folE
GTP cyclohydrolase I; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.799
EDP62362.1
COG0129 Dihydroxyacid dehydratase/phosphogluconate dehydratase; Belongs to the IlvD/Edd family.
 
  
 0.782
EDP66103.1
Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 0.770
EDP66215.1
Threonine dehydratase II.
 
 
 0.739
Your Current Organism:
alpha proteobacterium BAL199
NCBI taxonomy Id: 331869
Other names: a. proteobacterium BAL199
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