VFPFJ_11674 protein (Purpureocillium lilacinum)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

VFPFJ_11674

Zinc-binding dehydrogenase domain-containing protein. (319 aa)

Predicted Functional Partners:

VFPBJ_07585

0.810

VFPBJ_01684

0.475

PCL_12638

0.445

VFPFJ_08236

0.438

VFPFJ_10814

0.410

Your Current Organism:

Purpureocillium lilacinum

NCBI taxonomy Id: 33203
Other names: ATCC 10114, CBS 284.36, CCRC 31616, CCRC:31616, DSM 846, IMI 027830, JCM 9332, NCTC 584, NRRL 895, P. lilacinum, Paecilomyces lilacinum, Paecilomyces lilacinus, Penicillium lilacinum, Purpureocillium lilacinum (Thom) Luangsa-ard, Houbraken, Hywel-Jones & Samson 2011, QM 7592, VKM F-3193

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PCL_12638	VFPFJ_11674	A0A179GEB0	A0A179EZ53	GroES-like protein.	Zinc-binding dehydrogenase domain-containing protein.	0.445
VFPBJ_01684	VFPFJ_11674	A0A179HC57	A0A179EZ53	Indc11-like protein.	Zinc-binding dehydrogenase domain-containing protein.	0.475
VFPBJ_07585	VFPFJ_11674	A0A179GIE7	A0A179EZ53	12-oxophytodienoate reductase.	Zinc-binding dehydrogenase domain-containing protein.	0.810
VFPFJ_08236	VFPFJ_11674	A0A179H6R6	A0A179EZ53	Zinc-binding oxidoreductase CipB.	Zinc-binding dehydrogenase domain-containing protein.	0.438
VFPFJ_10814	VFPFJ_11674	A0A179GDD1	A0A179EZ53	Zinc alcohol dehydrogenase.	Zinc-binding dehydrogenase domain-containing protein.	0.410
VFPFJ_11674	PCL_12638	A0A179EZ53	A0A179GEB0	Zinc-binding dehydrogenase domain-containing protein.	GroES-like protein.	0.445
VFPFJ_11674	VFPBJ_01684	A0A179EZ53	A0A179HC57	Zinc-binding dehydrogenase domain-containing protein.	Indc11-like protein.	0.475
VFPFJ_11674	VFPBJ_07585	A0A179EZ53	A0A179GIE7	Zinc-binding dehydrogenase domain-containing protein.	12-oxophytodienoate reductase.	0.810
VFPFJ_11674	VFPFJ_08236	A0A179EZ53	A0A179H6R6	Zinc-binding dehydrogenase domain-containing protein.	Zinc-binding oxidoreductase CipB.	0.438
VFPFJ_11674	VFPFJ_10814	A0A179EZ53	A0A179GDD1	Zinc-binding dehydrogenase domain-containing protein.	Zinc alcohol dehydrogenase.	0.410

Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.899

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042438

Melanin biosynthetic process

6 of 17

2.41

4.67

4.27e-10

GO:0043473

Pigmentation

2 of 2

2.86

1.39

0.0030

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004503

Tyrosinase activity

4 of 7

2.62

3.21

9.56e-07

GO:0004497

Monooxygenase activity

6 of 211

1.32

1.39

7.60e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045009

Chitosome

2 of 3

2.69

1.02

0.0139

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6990

Tyrosinase copper-binding domain, and Cytochrome b561/ferric reductase transmembrane

8 of 11

2.73

8.28

4.61e-17

CL:6994

Tyrosinase copper-binding domain

5 of 5

2.86

5.28

1.33e-10

CL:786

RNA Polymerase II Pre-transcription Events, and Tyrosinase activity

3 of 86

1.41

0.63

0.0467

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00350

Tyrosine metabolism

11 of 89

1.96

6.28

9.48e-20

map01110

Biosynthesis of secondary metabolites

11 of 866

0.97

1.19

1.86e-09

map01100

Metabolic pathways

11 of 2708

0.47

0.4

0.00033

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5662702

Melanin biosynthesis

2 of 2

2.86

1.12

0.0096

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0033162

Melanosome membrane

3 of 4

2.74

2.29

6.30e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0479

Metal-binding

9 of 550

1.08

1.3

4.18e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00264

Common central domain of tyrosinase

9 of 12

2.74

9.71

3.79e-20

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR008922

Di-copper centre-containing domain superfamily

9 of 12

2.74

9.5

1.12e-19

IPR002227

Tyrosinase copper-binding domain

9 of 12

2.74

9.5

1.12e-19

IPR041640

Tyosinase, C-terminal

2 of 2

2.86

1.13

0.0091

IPR040632

Sulfotransferase, S. mansonii-type

2 of 5

2.47

0.89

0.0239

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