VFPFJ_10401 protein (Purpureocillium lilacinum)

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Known Interactions

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Predicted Interactions

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[Homology]

Score

VFPFJ_10401

Homoserine o-acetyltransferase protein. (335 aa)

Predicted Functional Partners:

VFPBJ_01266

0.474

VFPFJ_03847

0.451

VFPBJ_04935

0.448

VFPBJ_10640

0.438

PCL_04145

0.433

VFPBJ_09607

0.433

VFPFJ_05561

0.433

PCL_05318

0.433

Your Current Organism:

Purpureocillium lilacinum

NCBI taxonomy Id: 33203
Other names: ATCC 10114, CBS 284.36, CCRC 31616, CCRC:31616, DSM 846, IMI 027830, JCM 9332, NCTC 584, NRRL 895, P. lilacinum, Paecilomyces lilacinum, Paecilomyces lilacinus, Penicillium lilacinum, Purpureocillium lilacinum (Thom) Luangsa-ard, Houbraken, Hywel-Jones & Samson 2011, QM 7592, VKM F-3193

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PCL_04145	VFPBJ_01266	A0A179GK77	A0A179HAB5	Epoxide hydrolase-like protein.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.729
PCL_04145	VFPFJ_10401	A0A179GK77	A0A179GG84	Epoxide hydrolase-like protein.	Homoserine o-acetyltransferase protein.	0.433
PCL_05318	VFPBJ_01266	A0A179HLD9	A0A179HAB5	Non-heme chloroperoxidase.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.729
PCL_05318	VFPFJ_10401	A0A179HLD9	A0A179GG84	Non-heme chloroperoxidase.	Homoserine o-acetyltransferase protein.	0.433
VFPBJ_01266	PCL_04145	A0A179HAB5	A0A179GK77	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	Epoxide hydrolase-like protein.	0.729
VFPBJ_01266	PCL_05318	A0A179HAB5	A0A179HLD9	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	Non-heme chloroperoxidase.	0.729
VFPBJ_01266	VFPBJ_09607	A0A179HAB5	A0A179GVH3	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	Epoxide hydrolase.	0.729
VFPBJ_01266	VFPFJ_03847	A0A179HAB5	A0A179HP51	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	Ketose-bisphosphate aldolase class-II family protein.	0.660
VFPBJ_01266	VFPFJ_05561	A0A179HAB5	A0A179HGU9	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	Alpha/beta hydrolase fold protein.	0.729
VFPBJ_01266	VFPFJ_10401	A0A179HAB5	A0A179GG84	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	Homoserine o-acetyltransferase protein.	0.474
VFPBJ_04935	VFPBJ_10640	A0A179HSI6	A0A179G3B0	Fe-containing alcohol dehydrogenase.	Deoxyribose-phosphate aldolase.	0.717
VFPBJ_04935	VFPFJ_03847	A0A179HSI6	A0A179HP51	Fe-containing alcohol dehydrogenase.	Ketose-bisphosphate aldolase class-II family protein.	0.510
VFPBJ_04935	VFPFJ_10401	A0A179HSI6	A0A179GG84	Fe-containing alcohol dehydrogenase.	Homoserine o-acetyltransferase protein.	0.448
VFPBJ_09607	VFPBJ_01266	A0A179GVH3	A0A179HAB5	Epoxide hydrolase.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.729
VFPBJ_09607	VFPFJ_10401	A0A179GVH3	A0A179GG84	Epoxide hydrolase.	Homoserine o-acetyltransferase protein.	0.433
VFPBJ_10640	VFPBJ_04935	A0A179G3B0	A0A179HSI6	Deoxyribose-phosphate aldolase.	Fe-containing alcohol dehydrogenase.	0.717
VFPBJ_10640	VFPFJ_03847	A0A179G3B0	A0A179HP51	Deoxyribose-phosphate aldolase.	Ketose-bisphosphate aldolase class-II family protein.	0.409
VFPBJ_10640	VFPFJ_10401	A0A179G3B0	A0A179GG84	Deoxyribose-phosphate aldolase.	Homoserine o-acetyltransferase protein.	0.438
VFPFJ_03847	VFPBJ_01266	A0A179HP51	A0A179HAB5	Ketose-bisphosphate aldolase class-II family protein.	Multifunctional tryptophan biosynthesis protein; Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.	0.660
VFPFJ_03847	VFPBJ_04935	A0A179HP51	A0A179HSI6	Ketose-bisphosphate aldolase class-II family protein.	Fe-containing alcohol dehydrogenase.	0.510

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.81

expected number of edges:

11

PPI enrichment p-value:

3.6e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030834

Regulation of actin filament depolymerization

5 of 13

2.28

3.25

3.27e-07

GO:0030837

Negative regulation of actin filament polymerization

5 of 14

2.24

3.23

3.27e-07

GO:0051016

Barbed-end actin filament capping

4 of 10

2.29

2.93

1.74e-06

GO:0007010

Cytoskeleton organization

7 of 140

1.39

1.89

6.31e-07

GO:0030036

Actin cytoskeleton organization

5 of 76

1.51

1.72

3.18e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051015

Actin filament binding

6 of 24

2.09

3.68

1.01e-08

GO:0044877

Protein-containing complex binding

7 of 145

1.38

1.8

1.57e-06

GO:0005200

Structural constituent of cytoskeleton

3 of 10

2.17

1.73

0.00047

GO:0005515

Protein binding

7 of 607

0.75

0.51

0.0112

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015629

Actin cytoskeleton

10 of 59

1.92

5.33

4.84e-16

GO:0005869

Dynactin complex

4 of 4

2.69

3.62

1.67e-07

GO:0005856

Cytoskeleton

11 of 171

1.5

3.16

1.77e-14

GO:0008290

F-actin capping protein complex

3 of 3

2.69

2.73

8.80e-06

GO:0030479

Actin cortical patch

5 of 37

1.82

2.55

1.27e-06

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30323040

(2019) A Novel Actin Binding Drug with In Vivo Efficacy.

2 of 2

2.69

1.14

0.0086

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1450

Microtubule associated complex, and F-actin capping protein complex

7 of 11

2.5

6.12

4.14e-13

CL:1452

Dynactin complex, and Actin capping

5 of 5

2.69

4.72

1.07e-09

CL:2177

Actin cortical patch, and Actin polymerization or depolymerization

3 of 28

1.72

1.16

0.0042

CL:2198

Actin filament depolymerization, and Calponin homology domain

2 of 6

2.21

1.0

0.0141

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-109582

Hemostasis

5 of 80

1.49

1.42

0.00032

MAP-983231

Factors involved in megakaryocyte development and platelet production

3 of 32

1.66

0.87

0.0174

MAP-6807878

COPI-mediated anterograde transport

3 of 43

1.54

0.76

0.0266

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015629

Actin cytoskeleton

8 of 50

1.9

4.24

7.60e-12

GOCC:0005856

Cytoskeleton

10 of 134

1.56

3.22

1.25e-12

GOCC:0005875

Microtubule associated complex

4 of 13

2.18

2.6

6.51e-06

GOCC:0008290

F-actin capping protein complex

3 of 3

2.69

2.56

1.87e-05

GOCC:0005869

Dynactin complex

3 of 3

2.69

2.56

1.87e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0009

Actin-binding

3 of 12

2.09

1.65

0.00061

KW-0117

Actin capping

2 of 2

2.69

1.43

0.0025

KW-0206

Cytoskeleton

2 of 14

1.85

0.78

0.0325

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR042276

F-actin-capping protein subunit alpha/beta, domain 2

2 of 2

2.69

0.72

0.0496

IPR037282

F-actin-capping protein subunit alpha/beta

2 of 2

2.69

0.72

0.0496

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