VFPFJ_09577 protein (Purpureocillium lilacinum)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Cooccurrence

Coexpression

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Score

VFPFJ_09577

Ankyrin repeat and protein kinase domain-containing protein. (362 aa)

Predicted Functional Partners:

VFPFJ_06145

0.903

VFPFJ_07967

0.902

VFPBJ_03859

0.753

VFPFJ_10603

0.547

PCL_06033

0.538

PCL_01114

0.530

PCL_08573

0.527

VFPFJ_11424

0.505

VFPBJ_08752

0.502

Your Current Organism:

Purpureocillium lilacinum

NCBI taxonomy Id: 33203
Other names: ATCC 10114, CBS 284.36, CCRC 31616, CCRC:31616, DSM 846, IMI 027830, JCM 9332, NCTC 584, NRRL 895, P. lilacinum, Paecilomyces lilacinum, Paecilomyces lilacinus, Penicillium lilacinum, Purpureocillium lilacinum (Thom) Luangsa-ard, Houbraken, Hywel-Jones & Samson 2011, QM 7592, VKM F-3193

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PCL_01114	PCL_06033	A0A179FVR2	A0A179G9Y4	Ankyrin repeats (3 copies) domain-containing protein.	Ankyrin repeats (3 copies) domain-containing protein.	0.513
PCL_01114	PCL_08573	A0A179FVR2	A0A179HQU3	Ankyrin repeats (3 copies) domain-containing protein.	Ankyrin repeats (3 copies) domain-containing protein.	0.456
PCL_01114	VFPFJ_09577	A0A179FVR2	A0A179GTM5	Ankyrin repeats (3 copies) domain-containing protein.	Ankyrin repeat and protein kinase domain-containing protein.	0.530
PCL_06033	PCL_01114	A0A179G9Y4	A0A179FVR2	Ankyrin repeats (3 copies) domain-containing protein.	Ankyrin repeats (3 copies) domain-containing protein.	0.513
PCL_06033	PCL_08573	A0A179G9Y4	A0A179HQU3	Ankyrin repeats (3 copies) domain-containing protein.	Ankyrin repeats (3 copies) domain-containing protein.	0.501
PCL_06033	VFPBJ_08752	A0A179G9Y4	A0A179GEY1	Ankyrin repeats (3 copies) domain-containing protein.	Ankyrin repeats (3 copies) domain-containing protein.	0.536
PCL_06033	VFPFJ_09577	A0A179G9Y4	A0A179GTM5	Ankyrin repeats (3 copies) domain-containing protein.	Ankyrin repeat and protein kinase domain-containing protein.	0.538
PCL_08573	PCL_01114	A0A179HQU3	A0A179FVR2	Ankyrin repeats (3 copies) domain-containing protein.	Ankyrin repeats (3 copies) domain-containing protein.	0.456
PCL_08573	PCL_06033	A0A179HQU3	A0A179G9Y4	Ankyrin repeats (3 copies) domain-containing protein.	Ankyrin repeats (3 copies) domain-containing protein.	0.501
PCL_08573	VFPBJ_08752	A0A179HQU3	A0A179GEY1	Ankyrin repeats (3 copies) domain-containing protein.	Ankyrin repeats (3 copies) domain-containing protein.	0.483
PCL_08573	VFPFJ_09577	A0A179HQU3	A0A179GTM5	Ankyrin repeats (3 copies) domain-containing protein.	Ankyrin repeat and protein kinase domain-containing protein.	0.527
VFPBJ_03859	VFPFJ_09577	A0A179H4F7	A0A179GTM5	Phosphorylase superfamily protein.	Ankyrin repeat and protein kinase domain-containing protein.	0.753
VFPBJ_08752	PCL_06033	A0A179GEY1	A0A179G9Y4	Ankyrin repeats (3 copies) domain-containing protein.	Ankyrin repeats (3 copies) domain-containing protein.	0.536
VFPBJ_08752	PCL_08573	A0A179GEY1	A0A179HQU3	Ankyrin repeats (3 copies) domain-containing protein.	Ankyrin repeats (3 copies) domain-containing protein.	0.483
VFPBJ_08752	VFPFJ_09577	A0A179GEY1	A0A179GTM5	Ankyrin repeats (3 copies) domain-containing protein.	Ankyrin repeat and protein kinase domain-containing protein.	0.502
VFPFJ_06145	VFPFJ_09577	A0A179HJH2	A0A179GTM5	Pfs, NB-ARC and ankyrin domain-containingprotein.	Ankyrin repeat and protein kinase domain-containing protein.	0.903
VFPFJ_07967	VFPFJ_09577	A0A179H736	A0A179GTM5	Pfs domain-containingprotein.	Ankyrin repeat and protein kinase domain-containing protein.	0.902
VFPFJ_09577	PCL_01114	A0A179GTM5	A0A179FVR2	Ankyrin repeat and protein kinase domain-containing protein.	Ankyrin repeats (3 copies) domain-containing protein.	0.530
VFPFJ_09577	PCL_06033	A0A179GTM5	A0A179G9Y4	Ankyrin repeat and protein kinase domain-containing protein.	Ankyrin repeats (3 copies) domain-containing protein.	0.538
VFPFJ_09577	PCL_08573	A0A179GTM5	A0A179HQU3	Ankyrin repeat and protein kinase domain-containing protein.	Ankyrin repeats (3 copies) domain-containing protein.	0.527

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.826

expected number of edges:

12

PPI enrichment p-value:

1.85e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042274

Ribosomal small subunit biogenesis

6 of 82

2.23

4.13

2.29e-09

GO:0006412

Translation

7 of 363

1.65

2.66

4.73e-08

GO:0030490

Maturation of SSU-rRNA

4 of 67

2.14

2.6

5.68e-06

GO:0006364

rRNA processing

5 of 268

1.64

1.99

1.31e-05

GO:0000462

Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

3 of 52

2.13

1.86

0.00024

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

7 of 183

1.95

3.84

5.95e-10

GO:0030515

snoRNA binding

2 of 23

2.3

0.92

0.0206

GO:0003723

RNA binding

5 of 763

1.18

0.85

0.0053

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022627

Cytosolic small ribosomal subunit

5 of 27

2.63

4.96

2.91e-10

GO:0015935

Small ribosomal subunit

6 of 59

2.37

4.94

8.00e-11

GO:0005840

Ribosome

7 of 202

1.91

3.83

2.91e-10

GO:1990904

Ribonucleoprotein complex

8 of 551

1.53

2.65

1.59e-09

GO:0030684

Preribosome

4 of 107

1.94

2.35

9.86e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10688

Cytosolic small ribosomal subunit, and Ribosomal protein S8

5 of 13

2.95

5.34

1.20e-10

CL:11902

Preribosome, small subunit precursor

3 of 5

3.14

3.45

5.25e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

7 of 217

1.87

3.81

1.81e-10

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

8 of 182

2.01

4.81

1.23e-12

MAP-8868773

rRNA processing in the nucleus and cytosol

8 of 185

2.0

4.79

1.23e-12

MAP-72312

rRNA processing

8 of 188

1.99

4.76

1.23e-12

MAP-72695

Formation of the ternary complex, and subsequently, the 43S complex

6 of 103

2.13

4.25

4.48e-10

MAP-72702

Ribosomal scanning and start codon recognition

6 of 124

2.05

3.96

1.10e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015935

Small ribosomal subunit

7 of 73

2.35

5.74

7.38e-13

GOCC:0022627

Cytosolic small ribosomal subunit

6 of 39

2.55

5.72

4.85e-12

GOCC:1990904

Ribonucleoprotein complex

9 of 532

1.59

3.18

1.42e-11

GOCC:0030684

Preribosome

3 of 83

1.92

1.62

0.00054

GOCC:0030688

Preribosome, small subunit precursor

2 of 14

2.52

1.5

0.0017

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

7 of 107

2.18

5.19

2.26e-12

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03719

Ribosomal protein S5, C-terminal domain

2 of 2

3.37

1.62

0.0012

PF00333

Ribosomal protein S5, N-terminal domain

2 of 2

3.37

1.62

0.0012

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013810

Ribosomal protein S5, N-terminal

2 of 2

3.37

1.39

0.0032

IPR005324

Ribosomal protein S5, C-terminal

2 of 2

3.37

1.39

0.0032

IPR000851

Ribosomal protein S5

2 of 2

3.37

1.39

0.0032

IPR014721

Ribosomal protein S5 domain 2-type fold, subgroup

2 of 19

2.39

0.85

0.0279

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