PCL_01288 protein (Purpureocillium lilacinum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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Textmining

[Homology]

Score

PCL_01288

Homoserine dehydrogenase. (365 aa)

Predicted Functional Partners:

VFPBJ_02372

0.999

VFPBJ_08101

0.994

VFPBJ_05880

0.993

VFPBJ_00298

0.993

VFPFJ_01462

0.980

VFPBJ_05665

0.936

PCL_01958

0.935

VFPBJ_05878

0.912

VFPBJ_00600

0.912

VFPBJ_09556

0.908

Your Current Organism:

Purpureocillium lilacinum

NCBI taxonomy Id: 33203
Other names: ATCC 10114, CBS 284.36, CCRC 31616, CCRC:31616, DSM 846, IMI 027830, JCM 9332, NCTC 584, NRRL 895, P. lilacinum, Paecilomyces lilacinum, Paecilomyces lilacinus, Penicillium lilacinum, Purpureocillium lilacinum (Thom) Luangsa-ard, Houbraken, Hywel-Jones & Samson 2011, QM 7592, VKM F-3193

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PCL_01288	PCL_01958	A0A179GXS1	A0A179HI42	Homoserine dehydrogenase.	Homocysteine S-methyltransferase.	0.935
PCL_01288	VFPBJ_00298	A0A179GXS1	A0A179HXQ0	Homoserine dehydrogenase.	Aspartate-semialdehyde dehydrogenase.	0.993
PCL_01288	VFPBJ_00600	A0A179GXS1	A0A179HAC3	Homoserine dehydrogenase.	Cystathionine beta-lyase.	0.912
PCL_01288	VFPBJ_02372	A0A179GXS1	A0A179H0D2	Homoserine dehydrogenase.	Homoserine kinase.	0.999
PCL_01288	VFPBJ_05665	A0A179GXS1	A0A179GRW2	Homoserine dehydrogenase.	Acetolactate synthase small subunit.	0.936
PCL_01288	VFPBJ_05878	A0A179GXS1	A0A179GSJ3	Homoserine dehydrogenase.	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase.	0.912
PCL_01288	VFPBJ_05880	A0A179GXS1	A0A179HFE7	Homoserine dehydrogenase.	Threonine synthase.	0.993
PCL_01288	VFPBJ_08101	A0A179GXS1	A0A179GKI4	Homoserine dehydrogenase.	Aspartokinase.	0.994
PCL_01288	VFPBJ_09556	A0A179GXS1	A0A179GDX9	Homoserine dehydrogenase.	Cystathionine gamma-synthase, converts cysteine into cystathionine.	0.908
PCL_01288	VFPFJ_01462	A0A179GXS1	A0A179HZN0	Homoserine dehydrogenase.	Homoserine O-acetyltransferase.	0.980
PCL_01958	PCL_01288	A0A179HI42	A0A179GXS1	Homocysteine S-methyltransferase.	Homoserine dehydrogenase.	0.935
PCL_01958	VFPBJ_00298	A0A179HI42	A0A179HXQ0	Homocysteine S-methyltransferase.	Aspartate-semialdehyde dehydrogenase.	0.645
PCL_01958	VFPBJ_00600	A0A179HI42	A0A179HAC3	Homocysteine S-methyltransferase.	Cystathionine beta-lyase.	0.975
PCL_01958	VFPBJ_02372	A0A179HI42	A0A179H0D2	Homocysteine S-methyltransferase.	Homoserine kinase.	0.924
PCL_01958	VFPBJ_05878	A0A179HI42	A0A179GSJ3	Homocysteine S-methyltransferase.	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase.	0.990
PCL_01958	VFPBJ_05880	A0A179HI42	A0A179HFE7	Homocysteine S-methyltransferase.	Threonine synthase.	0.530
PCL_01958	VFPBJ_08101	A0A179HI42	A0A179GKI4	Homocysteine S-methyltransferase.	Aspartokinase.	0.692
PCL_01958	VFPBJ_09556	A0A179HI42	A0A179GDX9	Homocysteine S-methyltransferase.	Cystathionine gamma-synthase, converts cysteine into cystathionine.	0.966
VFPBJ_00298	PCL_01288	A0A179HXQ0	A0A179GXS1	Aspartate-semialdehyde dehydrogenase.	Homoserine dehydrogenase.	0.993
VFPBJ_00298	PCL_01958	A0A179HXQ0	A0A179HI42	Aspartate-semialdehyde dehydrogenase.	Homocysteine S-methyltransferase.	0.645

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.869

expected number of edges:

13

PPI enrichment p-value:

1.41e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006506

GPI anchor biosynthetic process

4 of 30

2.59

3.1

1.48e-06

GO:0009398

FMN biosynthetic process

2 of 2

3.47

2.13

0.00015

GO:0090407

Organophosphate biosynthetic process

6 of 572

1.49

1.83

8.75e-06

GO:1901137

Carbohydrate derivative biosynthetic process

6 of 638

1.44

1.74

1.06e-05

GO:0019637

Organophosphate metabolic process

7 of 939

1.34

1.61

7.64e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008531

Riboflavin kinase activity

2 of 2

3.47

1.59

0.0014

GO:0003919

FMN adenylyltransferase activity

2 of 5

3.07

1.45

0.0024

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030176

Integral component of endoplasmic reticulum membrane

2 of 70

1.92

0.72

0.0441

GO:0005789

Endoplasmic reticulum membrane

4 of 653

1.25

0.61

0.0419

GO:0031984

Organelle subcompartment

5 of 1567

0.97

0.52

0.0419

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12625

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

4 of 15

2.89

3.7

1.51e-07

CL:12628

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

3 of 10

2.94

2.71

1.12e-05

CL:9572

Purine nucleotide salvage, and Adenylate kinase activity

3 of 31

2.45

1.99

0.00019

CL:9944

Mixed, incl. Calcineurin-like phosphoesterase, and Nicotinamide nucleotide metabolic process

3 of 46

2.28

1.84

0.00032

CL:9958

Riboflavin kinase domain superfamily, and Nudix N-terminal

2 of 5

3.07

1.67

0.00098

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00563

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

4 of 29

2.6

3.87

4.55e-08

map00740

Riboflavin metabolism

3 of 79

2.04

1.86

0.00020

map01100

Metabolic pathways

9 of 6166

0.63

0.51

0.00067

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163125

Post-translational modification: synthesis of GPI-anchored proteins

4 of 30

2.59

3.46

2.92e-07

MAP-196843

Vitamin B2 (riboflavin) metabolism

2 of 6

2.99

1.6

0.0013

MAP-162710

Synthesis of glycosylphosphatidylinositol (GPI)

2 of 19

2.49

1.2

0.0063

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042765

GPI-anchor transamidase complex

2 of 6

2.99

1.33

0.0040

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023198

Phosphoglycolate phosphatase-like, domain 2

4 of 13

2.95

3.79

1.10e-07

IPR023465

Riboflavin kinase domain superfamily

3 of 3

3.47

3.34

9.32e-07

IPR015865

Riboflavin kinase domain, bacterial/eukaryotic

3 of 3

3.47

3.34

9.32e-07

IPR006439

HAD hydrolase, subfamily IA

4 of 26

2.65

3.31

6.34e-07

IPR041492

Haloacid dehalogenase-like hydrolase

4 of 28

2.62

3.3

6.34e-07

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00904

Riboflavin kinase

2 of 2

3.47

1.94

0.00033

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