VFPBJ_10208 protein (Purpureocillium lilacinum)

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Score

VFPBJ_10208

Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family. (484 aa)

Predicted Functional Partners:

VFPFJ_07000

0.941

VFPBJ_01285

0.938

VFPBJ_05346

0.928

VFPFJ_11347

0.924

PCL_11181

0.924

VFPFJ_06202

0.924

VFPFJ_11346

0.923

PCL_01116

0.923

VFPBJ_05915

0.923

VFPFJ_09993

0.922

Your Current Organism:

Purpureocillium lilacinum

NCBI taxonomy Id: 33203
Other names: ATCC 10114, CBS 284.36, CCRC 31616, CCRC:31616, DSM 846, IMI 027830, JCM 9332, NCTC 584, NRRL 895, P. lilacinum, Paecilomyces lilacinum, Paecilomyces lilacinus, Penicillium lilacinum, Purpureocillium lilacinum (Thom) Luangsa-ard, Houbraken, Hywel-Jones & Samson 2011, QM 7592, VKM F-3193

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PCL_01116	PCL_11181	A0A179GFV7	A0A179GPQ8	Alcohol dehydrogenase I.	Pyruvate decarboxylase.	0.944
PCL_01116	VFPBJ_05915	A0A179GFV7	A0A179GSK6	Alcohol dehydrogenase I.	Alcohol dehydrogenase I.	0.901
PCL_01116	VFPBJ_10208	A0A179GFV7	A0A179GYG7	Alcohol dehydrogenase I.	Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family.	0.923
PCL_01116	VFPFJ_06202	A0A179GFV7	A0A179HJH9	Alcohol dehydrogenase I.	Pyruvate decarboxylase.	0.942
PCL_01116	VFPFJ_11346	A0A179GFV7	A0A179FEA2	Alcohol dehydrogenase I.	Dehydrogenase-like protein.	0.901
PCL_01116	VFPFJ_11347	A0A179GFV7	A0A179FEK5	Alcohol dehydrogenase I.	Pyruvate decarboxylase.	0.975
PCL_11181	PCL_01116	A0A179GPQ8	A0A179GFV7	Pyruvate decarboxylase.	Alcohol dehydrogenase I.	0.944
PCL_11181	VFPBJ_05915	A0A179GPQ8	A0A179GSK6	Pyruvate decarboxylase.	Alcohol dehydrogenase I.	0.944
PCL_11181	VFPBJ_10208	A0A179GPQ8	A0A179GYG7	Pyruvate decarboxylase.	Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family.	0.924
PCL_11181	VFPFJ_06202	A0A179GPQ8	A0A179HJH9	Pyruvate decarboxylase.	Pyruvate decarboxylase.	0.905
PCL_11181	VFPFJ_11346	A0A179GPQ8	A0A179FEA2	Pyruvate decarboxylase.	Dehydrogenase-like protein.	0.944
PCL_11181	VFPFJ_11347	A0A179GPQ8	A0A179FEK5	Pyruvate decarboxylase.	Pyruvate decarboxylase.	0.912
VFPBJ_01285	VFPBJ_05346	A0A179I0I5	A0A179HFQ0	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Glutamate decarboxylase; Belongs to the group II decarboxylase family.	0.976
VFPBJ_01285	VFPBJ_10208	A0A179I0I5	A0A179GYG7	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family.	0.938
VFPBJ_01285	VFPFJ_07000	A0A179I0I5	A0A179HE45	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Acetyl-coenzyme A synthetase.	0.814
VFPBJ_05346	VFPBJ_01285	A0A179HFQ0	A0A179I0I5	Glutamate decarboxylase; Belongs to the group II decarboxylase family.	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.976
VFPBJ_05346	VFPBJ_10208	A0A179HFQ0	A0A179GYG7	Glutamate decarboxylase; Belongs to the group II decarboxylase family.	Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family.	0.928
VFPBJ_05915	PCL_01116	A0A179GSK6	A0A179GFV7	Alcohol dehydrogenase I.	Alcohol dehydrogenase I.	0.901
VFPBJ_05915	PCL_11181	A0A179GSK6	A0A179GPQ8	Alcohol dehydrogenase I.	Pyruvate decarboxylase.	0.944
VFPBJ_05915	VFPBJ_10208	A0A179GSK6	A0A179GYG7	Alcohol dehydrogenase I.	Retinal dehydrogenase 2; Belongs to the aldehyde dehydrogenase family.	0.923

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Network Stats

number of nodes:

6

number of edges:

8

average node degree:

2.67

avg. local clustering coefficient:

0.883

expected number of edges:

6

PPI enrichment p-value:

0.223

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006289

Nucleotide-excision repair

4 of 39

2.18

2.21

4.69e-05

GO:0000724

Double-strand break repair via homologous recombination

4 of 67

1.95

1.84

0.00018

GO:0006261

DNA-templated DNA replication

4 of 105

1.75

1.57

0.00044

GO:0007004

Telomere maintenance via telomerase

2 of 8

2.57

1.27

0.0048

GO:0022402

Cell cycle process

5 of 338

1.34

1.19

0.00072

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003684

Damaged DNA binding

3 of 27

2.22

1.51

0.0014

GO:0003697

Single-stranded DNA binding

3 of 36

2.09

1.45

0.0016

GO:0043047

Single-stranded telomeric DNA binding

2 of 6

2.69

1.22

0.0061

GO:0003677

DNA binding

5 of 796

0.97

0.57

0.0266

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030894

Replisome

4 of 14

2.63

3.49

2.67e-07

GO:0005662

DNA replication factor A complex

3 of 3

3.17

1.79e-06

GO:0000228

Nuclear chromosome

4 of 114

1.72

1.8

9.23e-05

GO:0000781

Chromosome, telomeric region

3 of 47

1.98

1.73

0.00034

GO:0005694

Chromosome

5 of 415

1.25

1.18

0.00034

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11570

DNA-templated DNA replication, and DNA Double-Strand Break Repair

7 of 169

1.79

3.13

9.93e-09

CL:11577

Mixed, incl. HDR through Homologous Recombination (HRR), and DNA strand elongation

5 of 96

1.89

2.52

2.56e-06

CL:11587

HDR through Homologous Recombination (HRR), and DNA damage checkpoint signaling

4 of 54

2.04

2.34

1.62e-05

CL:11599

HDR through Single Strand Annealing (SSA), and Sensing of DNA Double Strand Breaks

3 of 24

2.27

1.97

0.00017

CL:11637

DNA replication factor A complex, and RecQ family helicase-topoisomerase III complex

2 of 5

2.77

1.55

0.0015

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03420

Nucleotide excision repair

8 of 153

1.89

4.38

1.82e-12

map03430

Mismatch repair

7 of 140

1.87

3.87

1.00e-10

map03030

DNA replication

7 of 164

1.8

3.61

1.95e-10

map03440

Homologous recombination

7 of 184

1.75

3.42

3.21e-10

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5696395

Formation of Incision Complex in GG-NER

3 of 31

2.16

1.81

0.00032

MAP-6781827

Transcription-Coupled Nucleotide Excision Repair (TC-NER)

5 of 172

1.64

1.79

5.83e-05

MAP-5696398

Nucleotide Excision Repair

5 of 199

1.57

1.72

5.93e-05

MAP-5358606

Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)

2 of 7

2.63

1.68

0.00082

MAP-5696400

Dual Incision in GG-NER

4 of 117

1.71

1.61

0.00029

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005662

DNA replication factor A complex

3 of 5

2.95

2.69

1.22e-05

GOCC:0000228

Nuclear chromosome

4 of 164

1.56

1.41

0.00054

GOCC:0005634

Nucleus

7 of 1487

0.84

0.68

0.0015

GOCC:0032991

Protein-containing complex

9 of 2717

0.69

0.57

0.00054

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08784

Replication protein A C terminal

2 of 2

3.17

1.44

0.0025

PF01336

OB-fold nucleic acid binding domain

2 of 7

2.63

1.17

0.0075

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR040260

Replication factor A protein-like

3 of 3

3.17

2.69

1.32e-05

IPR012340

Nucleic acid-binding, OB-fold

4 of 61

1.99

1.95

0.00011

IPR014892

Replication protein A, C-terminal

2 of 2

3.17

1.45

0.0024

IPR004365

OB-fold nucleic acid binding domain, AA-tRNA synthetase-type

2 of 8

2.57

1.03

0.0135

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