STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PCL_07113Autophagy-like protein 3. (235 aa)    
Predicted Functional Partners:
VFPFJ_04588
Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...]
   
 0.900
PCL_12377
Autophagy-related protein 3.
    
 
 0.632
PCL_11206
Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy.
    
 
 0.628
VFPBJ_00245
Phosphatidylinositol 3-kinase VPS34.
      
 0.623
VFPBJ_07234
Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.
      
 0.623
VFPFJ_00723
VPS15 protein kinase.
      
 0.623
VFPFJ_05465
Uncharacterized protein.
      
 0.622
VFPFJ_09160
Beclin-1.
      
 0.621
VFPFJ_04535
Autophagy regulatory protein Atg2.
      
 0.620
VFPBJ_02712
Protein-vacuolar targeting protein Atg18.
      
 0.615
Your Current Organism:
Purpureocillium lilacinum
NCBI taxonomy Id: 33203
Other names: ATCC 10114, CBS 284.36, CCRC 31616, CCRC:31616, DSM 846, IMI 027830, JCM 9332, NCTC 584, NRRL 895, P. lilacinum, Paecilomyces lilacinum, Paecilomyces lilacinus, Penicillium lilacinum, Purpureocillium lilacinum (Thom) Luangsa-ard, Houbraken, Hywel-Jones & Samson 2011, QM 7592, VKM F-3193
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