STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDM76735.1AAA-like domain-containing protein. (729 aa)    
Predicted Functional Partners:
SDM29048.1
HNH endonuclease.
   
 
 0.798
SDM57209.1
HNH endonuclease.
   
 
 0.798
SDM76702.1
Replication-relaxation.
       0.569
SDM76801.1
N6-adenosine-specific RNA methylase IME4.
 
     0.524
SDM76596.1
Helix-turn-helix of DDE superfamily endonuclease.
 
     0.477
topA
DNA topoisomerase-1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
     
 0.457
SDM76774.1
Hypothetical protein.
       0.432
Your Current Organism:
Actinomyces ruminicola
NCBI taxonomy Id: 332524
Other names: A. ruminicola, Actinomyces ruminicola An et al. 2006 emend. Nouioui et al. 2018, CGMCC 1.5030, DSM 27982, JCM 13352, strain B71
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