node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FMG_0335 | clpP | FMG_0335 | FMG_1208 | ATP-dependent protease Clp ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | ATP-dependent protease Clp proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.951 |
FMG_0335 | dnaK | FMG_0335 | FMG_0780 | ATP-dependent protease Clp ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Heat shock protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.969 |
FMG_0335 | groL | FMG_0335 | FMG_0886 | ATP-dependent protease Clp ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Heat shock protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.653 |
FMG_0335 | grpE | FMG_0335 | FMG_0781 | ATP-dependent protease Clp ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...] | 0.791 |
FMG_0335 | lon | FMG_0335 | FMG_1206 | ATP-dependent protease Clp ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | ATP-dependent protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.692 |
FMG_1204 | FMG_1205 | FMG_1204 | FMG_1205 | Macrolide ABC transporter ATP-binding protein. | Putative phosphoesterase. | 0.610 |
FMG_1204 | clpP | FMG_1204 | FMG_1208 | Macrolide ABC transporter ATP-binding protein. | ATP-dependent protease Clp proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.469 |
FMG_1204 | clpX | FMG_1204 | FMG_1207 | Macrolide ABC transporter ATP-binding protein. | ATP-dependent Clp protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.479 |
FMG_1204 | lon | FMG_1204 | FMG_1206 | Macrolide ABC transporter ATP-binding protein. | ATP-dependent protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.623 |
FMG_1204 | tig | FMG_1204 | FMG_1209 | Macrolide ABC transporter ATP-binding protein. | FKBP-type peptidyl-prolyl cis-transisomerase; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. | 0.504 |
FMG_1205 | FMG_1204 | FMG_1205 | FMG_1204 | Putative phosphoesterase. | Macrolide ABC transporter ATP-binding protein. | 0.610 |
FMG_1205 | clpP | FMG_1205 | FMG_1208 | Putative phosphoesterase. | ATP-dependent protease Clp proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.592 |
FMG_1205 | clpX | FMG_1205 | FMG_1207 | Putative phosphoesterase. | ATP-dependent Clp protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. | 0.599 |
FMG_1205 | lon | FMG_1205 | FMG_1206 | Putative phosphoesterase. | ATP-dependent protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.778 |
FMG_1205 | tig | FMG_1205 | FMG_1209 | Putative phosphoesterase. | FKBP-type peptidyl-prolyl cis-transisomerase; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. | 0.516 |
clpB | clpP | FMG_1512 | FMG_1208 | ATP-dependent protease Clp ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent protease Clp proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.951 |
clpB | dnaK | FMG_1512 | FMG_0780 | ATP-dependent protease Clp ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat shock protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.969 |
clpB | groL | FMG_1512 | FMG_0886 | ATP-dependent protease Clp ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat shock protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.653 |
clpB | grpE | FMG_1512 | FMG_0781 | ATP-dependent protease Clp ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...] | 0.791 |
clpB | lon | FMG_1512 | FMG_1206 | ATP-dependent protease Clp ATP-binding subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | ATP-dependent protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.692 |