Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ENSGAFP00000001088annotation not available (425 aa)    
Predicted Functional Partners:
CCH79_00012961
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.822
CCH79_00017374
Daxx domain-containing protein.
    
 
 0.752
CCH79_00020043
Small ubiquitin-related modifier.
    
 0.748
DCAF7
WD_REPEATS_REGION domain-containing protein.
   
 
 0.699
ENSGAFP00000015861
E1A binding protein p300 b.
   
 0.685
CCH79_00013677
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.674
ENSGAFP00000024142
Ubiquitin-conjugating enzyme E2Ia.
    
 0.674
CCH79_00017765
Uncharacterized protein.
    
 0.657
CCH79_00013840
Peptidyl-prolyl cis-trans isomerase.
    
  0.638
CCH79_00019921
MBD domain-containing protein.
    
 0.613
Your Current Organism:
Gambusia affinis
NCBI taxonomy Id: 33528
Other names: G. affinis, western mosquitofish
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