STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCH79_00001348Uncharacterized protein. (611 aa)    
Predicted Functional Partners:
CCH79_00014728
DNA helicase; Belongs to the MCM family.
   
 
 0.994
MCM7
DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]
   
 
 0.988
CCH79_00000255
DNA helicase; Belongs to the MCM family.
   
 
 0.986
CCH79_00005389
DNA helicase; Belongs to the MCM family.
   
 
 0.982
CCH79_00005104
DNA helicase; Belongs to the MCM family.
   
 
 0.972
ENSGAFP00000020980
Minichromosome maintenance complex component 2.
   
 
 0.965
CCH79_00000001
MCM domain-containing protein; Belongs to the MCM family.
   
 
 0.943
CCH79_00017324
MCM domain-containing protein; Belongs to the MCM family.
   
 
 0.928
MCMDC2
MCM_lid domain-containing protein.
   
 
 0.912
CCH79_00001555
DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands.
   
  
 0.894
Your Current Organism:
Gambusia affinis
NCBI taxonomy Id: 33528
Other names: G. affinis, western mosquitofish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.