Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
ENSGAFP00000001855Negative regulator of ubiquitin-like proteins 1. (588 aa)    
Predicted Functional Partners:
ENSGAFP00000022428
NEDD8 ubiquitin like modifier, like.
    
 0.999
CCH79_00012188
26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.
    
 0.956
CCH79_00008700
VWFA domain-containing protein.
   
 
 0.935
CCH79_00012331
MPN domain-containing protein.
    
 0.935
CCH79_00011002
VWFA domain-containing protein.
   
 
 0.935
CCH79_00016225
ANK_REP_REGION domain-containing protein.
    
 
 0.924
CCH79_00019226
Rpn3_C domain-containing protein.
    
 0.923
CCH79_00014362
AAA domain-containing protein; Belongs to the AAA ATPase family.
    
 0.922
CCH79_00000221
AAA domain-containing protein; Belongs to the AAA ATPase family.
    
 0.921
CCH79_00007748
Proteasome subunit alpha type.
    
  0.920
Your Current Organism:
Gambusia affinis
NCBI taxonomy Id: 33528
Other names: G. affinis, western mosquitofish
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