STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCH79_00005728SET domain-containing protein. (379 aa)    
Predicted Functional Partners:
CCH79_00012961
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.845
H4C7
H4 clustered histone 7.
    
 0.814
CCH79_00007273
Histone-lysine N-methyltransferase, H3 lysine-79 specific.
   
 0.752
CCH79_00014971
PHD-type domain-containing protein.
    
 0.752
ENSGAFP00000002795
Retinoblastoma binding protein 5.
    
 0.738
CCH79_00001264
B30.2/SPRY domain-containing protein.
    
 0.736
CCH79_00013391
WD_REPEATS_REGION domain-containing protein.
    
 0.731
CCH79_00018016
Uncharacterized protein.
   
 0.719
CCH79_00019226
Rpn3_C domain-containing protein.
    
 0.711
CCH79_00003269
Uncharacterized protein.
   
 0.707
Your Current Organism:
Gambusia affinis
NCBI taxonomy Id: 33528
Other names: G. affinis, western mosquitofish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.