STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CCH79_00017664Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1470 aa)    
Predicted Functional Partners:
CCH79_00003415
PDZ domain-containing protein.
   
 0.976
CCH79_00013596
PDZ domain-containing protein.
   
 0.973
CCH79_00005071
Uncharacterized protein; Belongs to the MAGUK family.
     
 0.921
CCH79_00014570
PDZ domain-containing protein.
   
 0.917
CCH79_00017583
PDZ domain-containing protein.
   
 0.909
CCH79_00010404
USP domain-containing protein.
    
 0.863
CCH79_00015606
Uncharacterized protein.
    
 
 0.862
CCH79_00006954
Uncharacterized protein; Belongs to the AAA ATPase family.
   
 0.840
ENSGAFP00000025763
annotation not available
   
 0.840
ENSGAFP00000025770
Zgc:136908.
   
 0.840
Your Current Organism:
Gambusia affinis
NCBI taxonomy Id: 33528
Other names: G. affinis, western mosquitofish
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