STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AP3B2AP3B1_C domain-containing protein. (1185 aa)    
Predicted Functional Partners:
CCH79_00007192
Adaptin_N domain-containing protein.
   
 0.993
CCH79_00009024
Uncharacterized protein.
   
  0.988
CCH79_00009864
MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.
   
 0.982
CCH79_00001588
MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.
   
 0.982
AP3S1
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
    
 0.961
ENSGAFP00000013843
Adaptor related protein complex 3 subunit sigma 2.
    
 0.942
CCH79_00010407
AP-1 complex subunit gamma.
   
 0.931
CCH79_00015363
AP-4 complex subunit epsilon; AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system; Belongs to the adaptor complexes large subunit family.
   
 0.920
CCH79_00010152
Uncharacterized protein.
    
 0.915
CCH79_00015780
AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...]
   
 0.905
Your Current Organism:
Gambusia affinis
NCBI taxonomy Id: 33528
Other names: G. affinis, western mosquitofish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.