node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Neut_0235 | Neut_1038 | Neut_0235 | Neut_1038 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: neu:NE2457 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.916 |
Neut_0235 | cysG | Neut_0235 | Neut_1002 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: neu:NE2457 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Precorrin-2 dehydrogenase / uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.907 |
Neut_0235 | hemA | Neut_0235 | Neut_0826 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: neu:NE2457 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.871 |
Neut_0235 | hemC | Neut_0235 | Neut_1037 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: neu:NE2457 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.996 |
Neut_0235 | hemE | Neut_0235 | Neut_0603 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: neu:NE2457 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.778 |
Neut_0235 | hemL | Neut_0235 | Neut_1537 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: neu:NE2457 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: neu:NE1423 glutamate-1-semialdehyde 2,1-aminomutase protein. | 0.993 |
Neut_0829 | hemA | Neut_0829 | Neut_0826 | TIGRFAM: glutaredoxin-like protein; PFAM: glutaredoxin; KEGG: neu:NE1911 glutaredoxin-related protein; Belongs to the glutaredoxin family. Monothiol subfamily. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.559 |
Neut_0829 | prfA | Neut_0829 | Neut_0827 | TIGRFAM: glutaredoxin-like protein; PFAM: glutaredoxin; KEGG: neu:NE1911 glutaredoxin-related protein; Belongs to the glutaredoxin family. Monothiol subfamily. | Bacterial peptide chain release factor 1 (bRF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.572 |
Neut_0829 | prmC | Neut_0829 | Neut_0828 | TIGRFAM: glutaredoxin-like protein; PFAM: glutaredoxin; KEGG: neu:NE1911 glutaredoxin-related protein; Belongs to the glutaredoxin family. Monothiol subfamily. | [protein release factor]-glutamine N5-methyltransferase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | 0.558 |
Neut_1038 | Neut_0235 | Neut_1038 | Neut_0235 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: neu:NE2457 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.916 |
Neut_1038 | cysG | Neut_1038 | Neut_1002 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Precorrin-2 dehydrogenase / uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.997 |
Neut_1038 | hemA | Neut_1038 | Neut_0826 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.808 |
Neut_1038 | hemC | Neut_1038 | Neut_1037 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
Neut_1038 | hemE | Neut_1038 | Neut_0603 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.941 |
Neut_1038 | hemL | Neut_1038 | Neut_1537 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: neu:NE1423 glutamate-1-semialdehyde 2,1-aminomutase protein. | 0.692 |
cysG | Neut_0235 | Neut_1002 | Neut_0235 | Precorrin-2 dehydrogenase / uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: neu:NE2457 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.907 |
cysG | Neut_1038 | Neut_1002 | Neut_1038 | Precorrin-2 dehydrogenase / uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.997 |
cysG | gltX | Neut_1002 | Neut_0499 | Precorrin-2 dehydrogenase / uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. | 0.408 |
cysG | hemA | Neut_1002 | Neut_0826 | Precorrin-2 dehydrogenase / uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.818 |
cysG | hemC | Neut_1002 | Neut_1037 | Precorrin-2 dehydrogenase / uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.995 |