node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Neut_0235 | Neut_1038 | Neut_0235 | Neut_1038 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: neu:NE2457 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.916 |
Neut_0235 | Neut_2003 | Neut_0235 | Neut_2003 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: neu:NE2457 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | PFAM: beta-ketoacyl synthase; KEGG: neu:NE1389 putative type I polyketide synthase WcbR. | 0.488 |
Neut_0235 | cysG | Neut_0235 | Neut_1002 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: neu:NE2457 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Precorrin-2 dehydrogenase / uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.907 |
Neut_0235 | hemA | Neut_0235 | Neut_0826 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: neu:NE2457 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.871 |
Neut_0235 | hemC | Neut_0235 | Neut_1037 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: neu:NE2457 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.996 |
Neut_0235 | hemE | Neut_0235 | Neut_0603 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: neu:NE2457 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.778 |
Neut_0235 | hemL | Neut_0235 | Neut_1537 | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: neu:NE2457 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: neu:NE1423 glutamate-1-semialdehyde 2,1-aminomutase protein. | 0.993 |
Neut_1038 | Neut_0235 | Neut_1038 | Neut_0235 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: neu:NE2457 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.916 |
Neut_1038 | cysG | Neut_1038 | Neut_1002 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Precorrin-2 dehydrogenase / uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.997 |
Neut_1038 | hemA | Neut_1038 | Neut_0826 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.808 |
Neut_1038 | hemC | Neut_1038 | Neut_1037 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
Neut_1038 | hemE | Neut_1038 | Neut_0603 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.941 |
Neut_1038 | hemL | Neut_1038 | Neut_1537 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: neu:NE1423 glutamate-1-semialdehyde 2,1-aminomutase protein. | 0.692 |
Neut_1539 | Neut_1540 | Neut_1539 | Neut_1540 | PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: neu:NE1425 putative phosphomethylpyrimidine kinase. | PFAM: Rubredoxin-type Fe(Cys)4 protein; KEGG: neu:NE1426 rubredoxin:rubredoxin-type Fe(Cys)4 protein. | 0.725 |
Neut_1539 | hemL | Neut_1539 | Neut_1537 | PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: neu:NE1425 putative phosphomethylpyrimidine kinase. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: neu:NE1423 glutamate-1-semialdehyde 2,1-aminomutase protein. | 0.791 |
Neut_1539 | thiE | Neut_1539 | Neut_1538 | PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: neu:NE1425 putative phosphomethylpyrimidine kinase. | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.999 |
Neut_1540 | Neut_1539 | Neut_1540 | Neut_1539 | PFAM: Rubredoxin-type Fe(Cys)4 protein; KEGG: neu:NE1426 rubredoxin:rubredoxin-type Fe(Cys)4 protein. | PFAM: Phosphomethylpyrimidine kinase type-1; KEGG: neu:NE1425 putative phosphomethylpyrimidine kinase. | 0.725 |
Neut_1540 | hemL | Neut_1540 | Neut_1537 | PFAM: Rubredoxin-type Fe(Cys)4 protein; KEGG: neu:NE1426 rubredoxin:rubredoxin-type Fe(Cys)4 protein. | TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: neu:NE1423 glutamate-1-semialdehyde 2,1-aminomutase protein. | 0.582 |
Neut_1540 | thiE | Neut_1540 | Neut_1538 | PFAM: Rubredoxin-type Fe(Cys)4 protein; KEGG: neu:NE1426 rubredoxin:rubredoxin-type Fe(Cys)4 protein. | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.715 |
Neut_2003 | Neut_0235 | Neut_2003 | Neut_0235 | PFAM: beta-ketoacyl synthase; KEGG: neu:NE1389 putative type I polyketide synthase WcbR. | Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: neu:NE2457 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.488 |