node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Neut_0208 | Neut_0461 | Neut_0208 | Neut_0461 | TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: neu:NE0026 aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Serine palmitoyltransferase; PFAM: aminotransferase, class I and II; KEGG: neu:NE1655 aminotransferase class-I. | 0.968 |
Neut_0208 | Neut_2470 | Neut_0208 | Neut_2470 | TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: neu:NE0026 aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Urea amidolyase related protein; KEGG: neu:NE2420 biotin / lipoyl attachment:carbamoyl-phosphate synthase:DUF183; TIGRFAM: urea amidolyase related protein; PFAM: biotin/lipoyl attachment domain-containing protein; Allophanate hydrolase subunit 2; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein. | 0.446 |
Neut_0208 | bioB | Neut_0208 | Neut_2138 | TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: neu:NE0026 aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.992 |
Neut_0208 | bioD | Neut_0208 | Neut_2134 | TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: neu:NE0026 aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.999 |
Neut_0208 | bioF | Neut_0208 | Neut_2137 | TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: neu:NE0026 aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.985 |
Neut_0208 | bioH | Neut_0208 | Neut_2136 | TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: neu:NE0026 aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | Carboxylesterase BioH (pimeloyl-CoA synthesis); The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. | 0.426 |
Neut_0208 | birA | Neut_0208 | Neut_0232 | TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: neu:NE0026 aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.617 |
Neut_0461 | Neut_0208 | Neut_0461 | Neut_0208 | Serine palmitoyltransferase; PFAM: aminotransferase, class I and II; KEGG: neu:NE1655 aminotransferase class-I. | TIGRFAM: adenosylmethionine-8-amino-7-oxononanoate aminotransferase; PFAM: aminotransferase class-III; KEGG: neu:NE0026 aminotransferase class-III pyridoxal-phosphate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.968 |
Neut_0461 | Neut_2470 | Neut_0461 | Neut_2470 | Serine palmitoyltransferase; PFAM: aminotransferase, class I and II; KEGG: neu:NE1655 aminotransferase class-I. | Urea amidolyase related protein; KEGG: neu:NE2420 biotin / lipoyl attachment:carbamoyl-phosphate synthase:DUF183; TIGRFAM: urea amidolyase related protein; PFAM: biotin/lipoyl attachment domain-containing protein; Allophanate hydrolase subunit 2; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein. | 0.486 |
Neut_0461 | bioB | Neut_0461 | Neut_2138 | Serine palmitoyltransferase; PFAM: aminotransferase, class I and II; KEGG: neu:NE1655 aminotransferase class-I. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.817 |
Neut_0461 | bioD | Neut_0461 | Neut_2134 | Serine palmitoyltransferase; PFAM: aminotransferase, class I and II; KEGG: neu:NE1655 aminotransferase class-I. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.891 |
Neut_0461 | bioF | Neut_0461 | Neut_2137 | Serine palmitoyltransferase; PFAM: aminotransferase, class I and II; KEGG: neu:NE1655 aminotransferase class-I. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.920 |
Neut_0461 | bioH | Neut_0461 | Neut_2136 | Serine palmitoyltransferase; PFAM: aminotransferase, class I and II; KEGG: neu:NE1655 aminotransferase class-I. | Carboxylesterase BioH (pimeloyl-CoA synthesis); The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. | 0.929 |
Neut_0461 | birA | Neut_0461 | Neut_0232 | Serine palmitoyltransferase; PFAM: aminotransferase, class I and II; KEGG: neu:NE1655 aminotransferase class-I. | biotin--acetyl-CoA-carboxylase ligase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.508 |
Neut_2139 | bioB | Neut_2139 | Neut_2138 | KEGG: neu:NE2301 hypothetical protein. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.642 |
Neut_2139 | bioC | Neut_2139 | Neut_2135 | KEGG: neu:NE2301 hypothetical protein. | Biotin biosynthesis protein BioC; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.685 |
Neut_2139 | bioD | Neut_2139 | Neut_2134 | KEGG: neu:NE2301 hypothetical protein. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. | 0.627 |
Neut_2139 | bioF | Neut_2139 | Neut_2137 | KEGG: neu:NE2301 hypothetical protein. | 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.628 |
Neut_2139 | bioH | Neut_2139 | Neut_2136 | KEGG: neu:NE2301 hypothetical protein. | Carboxylesterase BioH (pimeloyl-CoA synthesis); The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. | 0.628 |
Neut_2139 | trmL | Neut_2139 | Neut_2140 | KEGG: neu:NE2301 hypothetical protein. | RNA methyltransferase, TrmH family, group 2; Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide. | 0.729 |