topA protein (Syntrophomonas wolfei Goettingen)

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topA

DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (694 aa)

Predicted Functional Partners:

Swol_2539

0.991

leuS

0.945

trmFO

0.925

rpoA

0.883

polA

0.871

Swol_2010

0.863

Swol_2075

0.863

Swol_0839

0.838

recA

0.807

rnhA

0.797

Your Current Organism:

Syntrophomonas wolfei Goettingen

NCBI taxonomy Id: 335541
Other names: S. wolfei subsp. wolfei str. Goettingen G311, Syntrophomonas wolfei str. Goettingen, Syntrophomonas wolfei subsp. wolfei Goettingen, Syntrophomonas wolfei subsp. wolfei str. Goettingen, Syntrophomonas wolfei subsp. wolfei str. Goettingen G311, Syntrophomonas wolfei subsp. wolfei str. Gottingen, Syntrophomonas wolfei subsp. wolfei strain Goettingen

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Swol_0839	Swol_2539	Swol_0839	Swol_2539	KEGG: tte:TTE1450 predicted Rossmann-fold nucleotide-binding protein involved in DNA uptake.	Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	0.549
Swol_0839	recA	Swol_0839	Swol_1255	KEGG: tte:TTE1450 predicted Rossmann-fold nucleotide-binding protein involved in DNA uptake.	RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.521
Swol_0839	topA	Swol_0839	Swol_0840	KEGG: tte:TTE1450 predicted Rossmann-fold nucleotide-binding protein involved in DNA uptake.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.838
Swol_0839	trmFO	Swol_0839	Swol_0841	KEGG: tte:TTE1450 predicted Rossmann-fold nucleotide-binding protein involved in DNA uptake.	Gid protein; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily.	0.618
Swol_2010	Swol_2075	Swol_2010	Swol_2075	KEGG: ttj:TTHA1020 hypothetical protein.	KEGG: ttj:TTHA1020 hypothetical protein.	0.982
Swol_2010	polA	Swol_2010	Swol_2017	KEGG: ttj:TTHA1020 hypothetical protein.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.984
Swol_2010	recA	Swol_2010	Swol_1255	KEGG: ttj:TTHA1020 hypothetical protein.	RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.840
Swol_2010	rpoA	Swol_2010	Swol_2304	KEGG: ttj:TTHA1020 hypothetical protein.	DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.990
Swol_2010	topA	Swol_2010	Swol_0840	KEGG: ttj:TTHA1020 hypothetical protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.863
Swol_2075	Swol_2010	Swol_2075	Swol_2010	KEGG: ttj:TTHA1020 hypothetical protein.	KEGG: ttj:TTHA1020 hypothetical protein.	0.982
Swol_2075	polA	Swol_2075	Swol_2017	KEGG: ttj:TTHA1020 hypothetical protein.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.984
Swol_2075	recA	Swol_2075	Swol_1255	KEGG: ttj:TTHA1020 hypothetical protein.	RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.840
Swol_2075	rpoA	Swol_2075	Swol_2304	KEGG: ttj:TTHA1020 hypothetical protein.	DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.990
Swol_2075	topA	Swol_2075	Swol_0840	KEGG: ttj:TTHA1020 hypothetical protein.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.863
Swol_2539	Swol_0839	Swol_2539	Swol_0839	Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	KEGG: tte:TTE1450 predicted Rossmann-fold nucleotide-binding protein involved in DNA uptake.	0.549
Swol_2539	polA	Swol_2539	Swol_2017	Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.714
Swol_2539	recA	Swol_2539	Swol_1255	Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.521
Swol_2539	rnhA	Swol_2539	Swol_2115	Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	RNase HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	0.740
Swol_2539	rpoA	Swol_2539	Swol_2304	Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	DNA-directed RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.507
Swol_2539	topA	Swol_2539	Swol_0840	Single-strand binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.991

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