node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Swol_1105 | mutM | Swol_1105 | Swol_2016 | KEGG: sth:STH2899 DNA-dependent DNA polymerase family X. | Formamidopyrimidine-DNA glycosylase / DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.407 |
Swol_1105 | nth | Swol_1105 | Swol_0961 | KEGG: sth:STH2899 DNA-dependent DNA polymerase family X. | DNA-(apurinic or apyrimidinic site) lyase / endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.565 |
Swol_1105 | polA | Swol_1105 | Swol_2017 | KEGG: sth:STH2899 DNA-dependent DNA polymerase family X. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.945 |
Swol_1105 | uvrC | Swol_1105 | Swol_0254 | KEGG: sth:STH2899 DNA-dependent DNA polymerase family X. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.431 |
Swol_2013 | Swol_2015 | Swol_2013 | Swol_2015 | Secreted protein; Similar to catalytic domain of murein transglycosylase; KEGG: cac:CAC1100 secreted protein, similar to catalytic domain of murein transglycosylase. | Integral membrane protein; Probably functions as a manganese efflux pump. | 0.613 |
Swol_2013 | coaE | Swol_2013 | Swol_2014 | Secreted protein; Similar to catalytic domain of murein transglycosylase; KEGG: cac:CAC1100 secreted protein, similar to catalytic domain of murein transglycosylase. | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.716 |
Swol_2013 | mutM | Swol_2013 | Swol_2016 | Secreted protein; Similar to catalytic domain of murein transglycosylase; KEGG: cac:CAC1100 secreted protein, similar to catalytic domain of murein transglycosylase. | Formamidopyrimidine-DNA glycosylase / DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.408 |
Swol_2013 | polA | Swol_2013 | Swol_2017 | Secreted protein; Similar to catalytic domain of murein transglycosylase; KEGG: cac:CAC1100 secreted protein, similar to catalytic domain of murein transglycosylase. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.531 |
Swol_2015 | Swol_2013 | Swol_2015 | Swol_2013 | Integral membrane protein; Probably functions as a manganese efflux pump. | Secreted protein; Similar to catalytic domain of murein transglycosylase; KEGG: cac:CAC1100 secreted protein, similar to catalytic domain of murein transglycosylase. | 0.613 |
Swol_2015 | coaE | Swol_2015 | Swol_2014 | Integral membrane protein; Probably functions as a manganese efflux pump. | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.884 |
Swol_2015 | mutM | Swol_2015 | Swol_2016 | Integral membrane protein; Probably functions as a manganese efflux pump. | Formamidopyrimidine-DNA glycosylase / DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.660 |
Swol_2015 | polA | Swol_2015 | Swol_2017 | Integral membrane protein; Probably functions as a manganese efflux pump. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.550 |
coaE | Swol_2013 | Swol_2014 | Swol_2013 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Secreted protein; Similar to catalytic domain of murein transglycosylase; KEGG: cac:CAC1100 secreted protein, similar to catalytic domain of murein transglycosylase. | 0.716 |
coaE | Swol_2015 | Swol_2014 | Swol_2015 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Integral membrane protein; Probably functions as a manganese efflux pump. | 0.884 |
coaE | guaA | Swol_2014 | Swol_1784 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.403 |
coaE | mutM | Swol_2014 | Swol_2016 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | Formamidopyrimidine-DNA glycosylase / DNA-(apurinic or apyrimidinic site) lyase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. | 0.980 |
coaE | nth | Swol_2014 | Swol_0961 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | DNA-(apurinic or apyrimidinic site) lyase / endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.434 |
coaE | polA | Swol_2014 | Swol_2017 | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. | 0.837 |
guaA | coaE | Swol_1784 | Swol_2014 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.403 |
guaA | gyrB | Swol_1784 | Swol_0005 | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.569 |