STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate. Catalyzes the reduction of oxaloacetate more efficiently than the oxidation of malate. (329 aa)    
Predicted Functional Partners:
Sfum_2336
Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.997
Sfum_2105
PFAM: Citrate synthase; KEGG: tth:TTC0978 citrate synthase; Belongs to the citrate synthase family.
  
 0.993
Sfum_1533
PFAM: Citrate synthase; KEGG: tth:TTC0978 citrate synthase; Belongs to the citrate synthase family.
  
 0.992
Sfum_0461
Pyruvate carboxylase subunit B; PFAM: biotin/lipoyl attachment domain-containing protein; pyruvate carboxyltransferase; Conserved carboxylase region; KEGG: mja:MJ1231 pyruvate carboxylase subunit B.
    
 0.989
fumC
Fumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.979
Sfum_2777
Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+))., Phosphate acetyltransferase; PFAM: phosphate acetyl/butaryl transferase; malic enzyme domain protein; malic enzyme, NAD-binding; KEGG: gsu:GSU1700 phosphate acetyltransferase.
  
 0.973
Sfum_3896
TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: tvo:TVN0195 isocitrate dehydrogenase.
  
 
 0.963
Sfum_0676
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha / biotin carboxylase; PFAM: ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; RimK domain protein ATP-grasp; KEGG: sat:SYN_01041 pyruvate carboxylase biotin carboxylase subunit.
  
 0.943
pckG
Phosphoenolpyruvate carboxykinase (GTP); Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.
 
  
 0.938
Sfum_0677
PFAM: pyruvate carboxyltransferase; KEGG: sat:SYN_01040 pyruvate carboxylase carboxyltransferase subunit.
    
 0.925
Your Current Organism:
Syntrophobacter fumaroxidans
NCBI taxonomy Id: 335543
Other names: S. fumaroxidans MPOB, Syntrophobacter fumaroxidans DSM 10017, Syntrophobacter fumaroxidans MPOB, Syntrophobacter fumaroxidans str. MPOB, Syntrophobacter fumaroxidans strain MPOB, Syntrophobacter sp. DSM 10017, syntrophic propionate-oxidizing bacterium DSM 10017
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