STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (650 aa)    
Predicted Functional Partners:
Sfum_1533
PFAM: Citrate synthase; KEGG: tth:TTC0978 citrate synthase; Belongs to the citrate synthase family.
  
 0.971
Sfum_2105
PFAM: Citrate synthase; KEGG: tth:TTC0978 citrate synthase; Belongs to the citrate synthase family.
  
 0.971
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
   
 
 0.955
Sfum_0708
PFAM: CoA-binding domain protein; KEGG: sat:SYN_02609 acetyl-CoA synthetase beta subunit.
    
 0.951
Sfum_1966
PFAM: CoA-binding domain protein; KEGG: mbu:Mbur_1347 acyl-CoA synthetase.
    
 0.951
Sfum_2466
PFAM: CoA-binding domain protein; KEGG: afu:AF1211 conserved hypothetical protein.
    
 0.951
Sfum_1163
Coenzyme A transferase; CoA transferase having broad substrate specificity for short- chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons. Belongs to the 3-oxoacid CoA-transferase family.
    
 0.944
Sfum_2280
KEGG: bur:Bcep18194_C7332 acetyl-CoA acetyltransferase; TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.943
Sfum_3582
TIGRFAM: acetyl-CoA acetyltransferases; PFAM: Thiolase; KEGG: chy:CHY_1288 acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
  
 
 0.943
Sfum_1472
Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
  
 
 0.941
Your Current Organism:
Syntrophobacter fumaroxidans
NCBI taxonomy Id: 335543
Other names: S. fumaroxidans MPOB, Syntrophobacter fumaroxidans DSM 10017, Syntrophobacter fumaroxidans MPOB, Syntrophobacter fumaroxidans str. MPOB, Syntrophobacter fumaroxidans strain MPOB, Syntrophobacter sp. DSM 10017, syntrophic propionate-oxidizing bacterium DSM 10017
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