STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dmdAGcvT-like Aminomethyltransferase protein; Major contributor to the demethylation of dimethlysulfonioproprionate (DMSP). Demethylates DMSP to methyl- mercaptopropionate (MMPA); Belongs to the GcvT family. DmdA subfamily. (369 aa)    
Predicted Functional Partners:
gcvP
Glycine cleavage system protein P2 gcvP; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
 
 0.993
gcvH
Glycine cleavage H-protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 
 0.899
pdhD
Dihydrolipoyl dehydrogenase.
  
 0.846
mmgC
acyl-CoA dehydrogenase.
  
 
 0.816
mhpC
Hydrolase; Alpha/beta hydrolase fold family.
  
    0.775
fadD
Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II.
     
 0.774
sucC
Succinyl-CoA synthetase beta chain (SCS-beta); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
  
 0.772
sdhC
Succinate dehydrogenase cytochrome b.
  
    0.745
sdhB
Succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
  
   0.740
sdhA
Succinate dehydrogenase; Flavoprotein chain, sdhA; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
  
    0.730
Your Current Organism:
Pelagibacter ubique HTCC1062
NCBI taxonomy Id: 335992
Other names: C. Pelagibacter ubique HTCC1062, Candidatus Pelagibacter ubique HTCC1062, Candidatus Pelagibacter ubique str. HTCC1062, Candidatus Pelagibacter ubique strain HTCC1062
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.