node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dcd | hisD | SAR11_0472 | SAR11_0475 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.782 |
dcd | murA | SAR11_0472 | SAR11_0473 | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.947 |
hisA | hisB | SAR11_0330 | SAR11_0332 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate dehydratase; Half of bifunctional hisB. | 0.996 |
hisA | hisC | SAR11_0330 | SAR11_0216 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.955 |
hisA | hisD | SAR11_0330 | SAR11_0475 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.922 |
hisA | hisF | SAR11_0330 | SAR11_0329 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit of hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | SAR11_0330 | SAR11_0480 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.962 |
hisA | hisH | SAR11_0330 | SAR11_0331 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit of hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | SAR11_0330 | SAR11_1246 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | 0.998 |
hisA | hisZ | SAR11_0330 | SAR11_0479 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | histidine-tRNA ligase. | 0.882 |
hisB | hisA | SAR11_0332 | SAR11_0330 | Imidazoleglycerol-phosphate dehydratase; Half of bifunctional hisB. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.996 |
hisB | hisC | SAR11_0332 | SAR11_0216 | Imidazoleglycerol-phosphate dehydratase; Half of bifunctional hisB. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | SAR11_0332 | SAR11_0475 | Imidazoleglycerol-phosphate dehydratase; Half of bifunctional hisB. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.996 |
hisB | hisF | SAR11_0332 | SAR11_0329 | Imidazoleglycerol-phosphate dehydratase; Half of bifunctional hisB. | Imidazole glycerol phosphate synthase subunit of hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | SAR11_0332 | SAR11_0480 | Imidazoleglycerol-phosphate dehydratase; Half of bifunctional hisB. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.977 |
hisB | hisH | SAR11_0332 | SAR11_0331 | Imidazoleglycerol-phosphate dehydratase; Half of bifunctional hisB. | Imidazole glycerol phosphate synthase subunit of hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | SAR11_0332 | SAR11_1246 | Imidazoleglycerol-phosphate dehydratase; Half of bifunctional hisB. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | 0.986 |
hisB | hisZ | SAR11_0332 | SAR11_0479 | Imidazoleglycerol-phosphate dehydratase; Half of bifunctional hisB. | histidine-tRNA ligase. | 0.934 |
hisC | hisA | SAR11_0216 | SAR11_0330 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.955 |
hisC | hisB | SAR11_0216 | SAR11_0332 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Imidazoleglycerol-phosphate dehydratase; Half of bifunctional hisB. | 0.999 |