node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCX90741.1 | SCX90772.1 | SAMN05660710_00186 | SAMN05660710_00187 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
SCX90741.1 | SCX97495.1 | SAMN05660710_00186 | SAMN05660710_00411 | Acetolactate synthase, small subunit. | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 0.990 |
SCX90741.1 | SCY78751.1 | SAMN05660710_00186 | SAMN05660710_02784 | Acetolactate synthase, small subunit. | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 0.994 |
SCX90741.1 | SCY94508.1 | SAMN05660710_00186 | SAMN05660710_03622 | Acetolactate synthase, small subunit. | Threonine dehydratase. | 0.956 |
SCX90741.1 | SCY94635.1 | SAMN05660710_00186 | SAMN05660710_03634 | Acetolactate synthase, small subunit. | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 0.953 |
SCX90741.1 | ilvA | SAMN05660710_00186 | SAMN05660710_01644 | Acetolactate synthase, small subunit. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.974 |
SCX90741.1 | ilvC | SAMN05660710_00186 | SAMN05660710_01801 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
SCX90741.1 | leuA | SAMN05660710_00186 | SAMN05660710_03082 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.973 |
SCX90741.1 | leuB | SAMN05660710_00186 | SAMN05660710_01177 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.987 |
SCX90741.1 | leuD | SAMN05660710_00186 | SAMN05660710_02647 | Acetolactate synthase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.941 |
SCX90772.1 | SCX90741.1 | SAMN05660710_00187 | SAMN05660710_00186 | Acetolactate synthase, large subunit. | Acetolactate synthase, small subunit. | 0.999 |
SCX90772.1 | SCY78751.1 | SAMN05660710_00187 | SAMN05660710_02784 | Acetolactate synthase, large subunit. | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | 0.810 |
SCX90772.1 | SCY94508.1 | SAMN05660710_00187 | SAMN05660710_03622 | Acetolactate synthase, large subunit. | Threonine dehydratase. | 0.931 |
SCX90772.1 | SCY94635.1 | SAMN05660710_00187 | SAMN05660710_03634 | Acetolactate synthase, large subunit. | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 0.843 |
SCX90772.1 | ilvA | SAMN05660710_00187 | SAMN05660710_01644 | Acetolactate synthase, large subunit. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.966 |
SCX90772.1 | ilvC | SAMN05660710_00187 | SAMN05660710_01801 | Acetolactate synthase, large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.995 |
SCX90772.1 | leuA | SAMN05660710_00187 | SAMN05660710_03082 | Acetolactate synthase, large subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.975 |
SCX90772.1 | leuB | SAMN05660710_00187 | SAMN05660710_01177 | Acetolactate synthase, large subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.974 |
SCX90772.1 | leuD | SAMN05660710_00187 | SAMN05660710_02647 | Acetolactate synthase, large subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.900 |
SCX97495.1 | SCX90741.1 | SAMN05660710_00411 | SAMN05660710_00186 | Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit. | 0.990 |