node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCY22966.1 | SCY52201.1 | SAMN05660710_00978 | SAMN05660710_01820 | Phosphoserine phosphatase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.516 |
SCY22966.1 | gcvP | SAMN05660710_00978 | SAMN05660710_01191 | Phosphoserine phosphatase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.419 |
SCY22966.1 | glyA | SAMN05660710_00978 | SAMN05660710_02614 | Phosphoserine phosphatase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.967 |
SCY29334.1 | SCY52201.1 | SAMN05660710_01193 | SAMN05660710_01820 | Aminomethyltransferase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.903 |
SCY29334.1 | fhs | SAMN05660710_01193 | SAMN05660710_00272 | Aminomethyltransferase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.909 |
SCY29334.1 | folD-2 | SAMN05660710_01193 | SAMN05660710_03162 | Aminomethyltransferase. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.932 |
SCY29334.1 | gcvH | SAMN05660710_01193 | SAMN05660710_01192 | Aminomethyltransferase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.999 |
SCY29334.1 | gcvP | SAMN05660710_01193 | SAMN05660710_01191 | Aminomethyltransferase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
SCY29334.1 | glyA | SAMN05660710_01193 | SAMN05660710_02614 | Aminomethyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.985 |
SCY29334.1 | purH | SAMN05660710_01193 | SAMN05660710_00950 | Aminomethyltransferase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.914 |
SCY29334.1 | purN | SAMN05660710_01193 | SAMN05660710_01408 | Aminomethyltransferase. | Phosphoribosylglycinamide formyltransferase-1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.910 |
SCY29334.1 | purU-2 | SAMN05660710_01193 | SAMN05660710_03173 | Aminomethyltransferase. | Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.886 |
SCY52201.1 | SCY22966.1 | SAMN05660710_01820 | SAMN05660710_00978 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Phosphoserine phosphatase. | 0.516 |
SCY52201.1 | SCY29334.1 | SAMN05660710_01820 | SAMN05660710_01193 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase. | 0.903 |
SCY52201.1 | fhs | SAMN05660710_01820 | SAMN05660710_00272 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.713 |
SCY52201.1 | folD-2 | SAMN05660710_01820 | SAMN05660710_03162 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.932 |
SCY52201.1 | gcvH | SAMN05660710_01820 | SAMN05660710_01192 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.452 |
SCY52201.1 | gcvP | SAMN05660710_01820 | SAMN05660710_01191 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.836 |
SCY52201.1 | glyA | SAMN05660710_01820 | SAMN05660710_02614 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.960 |
SCY52201.1 | purH | SAMN05660710_01820 | SAMN05660710_00950 | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.661 |