node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KKO44927.1 | pdxA | WG68_13745 | WG68_13775 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | 0.758 |
KKO47123.1 | pdxA | WG68_00240 | WG68_13775 | Threonine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | 0.812 |
KKO47123.1 | serC | WG68_00240 | WG68_03980 | Threonine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. | 0.919 |
apaG | apaH | WG68_13765 | WG68_13760 | Heavy metal transporter; Protein associated with Co2+ and Mg2+ efflux; Derived by automated computational analysis using gene prediction method: Protein Homology. | Diadenosine tetraphosphatase; Hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.962 |
apaG | lptD | WG68_13765 | WG68_13785 | Heavy metal transporter; Protein associated with Co2+ and Mg2+ efflux; Derived by automated computational analysis using gene prediction method: Protein Homology. | Organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. | 0.791 |
apaG | pdxA | WG68_13765 | WG68_13775 | Heavy metal transporter; Protein associated with Co2+ and Mg2+ efflux; Derived by automated computational analysis using gene prediction method: Protein Homology. | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | 0.846 |
apaG | rsmA | WG68_13765 | WG68_13770 | Heavy metal transporter; Protein associated with Co2+ and Mg2+ efflux; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.949 |
apaG | surA | WG68_13765 | WG68_13780 | Heavy metal transporter; Protein associated with Co2+ and Mg2+ efflux; Derived by automated computational analysis using gene prediction method: Protein Homology. | Peptidylprolyl isomerase; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. | 0.829 |
apaH | apaG | WG68_13760 | WG68_13765 | Diadenosine tetraphosphatase; Hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; Derived by automated computational analysis using gene prediction method: Protein Homology. | Heavy metal transporter; Protein associated with Co2+ and Mg2+ efflux; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.962 |
apaH | lptD | WG68_13760 | WG68_13785 | Diadenosine tetraphosphatase; Hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; Derived by automated computational analysis using gene prediction method: Protein Homology. | Organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. | 0.831 |
apaH | pdxA | WG68_13760 | WG68_13775 | Diadenosine tetraphosphatase; Hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; Derived by automated computational analysis using gene prediction method: Protein Homology. | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | 0.885 |
apaH | rsmA | WG68_13760 | WG68_13770 | Diadenosine tetraphosphatase; Hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.911 |
apaH | surA | WG68_13760 | WG68_13780 | Diadenosine tetraphosphatase; Hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; Derived by automated computational analysis using gene prediction method: Protein Homology. | Peptidylprolyl isomerase; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. | 0.863 |
gyrB | pdxA | WG68_08135 | WG68_13775 | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | 0.810 |
lptD | apaG | WG68_13785 | WG68_13765 | Organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. | Heavy metal transporter; Protein associated with Co2+ and Mg2+ efflux; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.791 |
lptD | apaH | WG68_13785 | WG68_13760 | Organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. | Diadenosine tetraphosphatase; Hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.831 |
lptD | pdxA | WG68_13785 | WG68_13775 | Organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | 0.816 |
lptD | rsmA | WG68_13785 | WG68_13770 | Organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. | 0.877 |
lptD | surA | WG68_13785 | WG68_13780 | Organic solvent tolerance protein; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. | Peptidylprolyl isomerase; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. | 0.935 |
pdxA | KKO44927.1 | WG68_13775 | WG68_13745 | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.758 |