STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)    
Predicted Functional Partners:
TNFRSF4
TNF receptor superfamily member 4.
    
 0.992
TNFRSF9
TNF receptor superfamily member 9.
   
  
 0.674
CD28
CD28 molecule.
   
  
 0.672
CD27
CD27 molecule.
      
 0.662
TNFSF9
TNF superfamily member 9; Belongs to the tumor necrosis factor family.
  
   
 0.622
CD40LG
CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
      
 0.597
IL4
Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.
  
   
 0.595
ICOS
Inducible T cell costimulator.
   
  
 0.589
TNFRSF8
TNF receptor superfamily member 8.
      
 0.539
TNFSF18
TNF superfamily member 18.
      
 0.532
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.