TELO2 protein (Colobus angolensis) - STRING interaction network

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Predicted Interactions

gene neighborhood

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Score

TELO2

Telomere maintenance 2. (837 aa)

Predicted Functional Partners:

TTI1

0.998

MTOR

0.995

FANCM

0.990

ATR

0.983

TTI2

0.958

ATM

0.943

RUVBL2

0.938

SMG1

0.935

RUVBL1

0.932

PRKDC

0.926

Your Current Organism:

Colobus angolensis

NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	ATR	ENSCANP00000015871	ENSCANP00000035545	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.998
ATM	FANCM	ENSCANP00000015871	ENSCANP00000012257	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	FA complementation group M.	0.780
ATM	MTOR	ENSCANP00000015871	ENSCANP00000021964	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.630
ATM	PRKDC	ENSCANP00000015871	ENSCANP00000015005	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.827
ATM	SMG1	ENSCANP00000015871	ENSCANP00000021914	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family.	0.688
ATM	TELO2	ENSCANP00000015871	ENSCANP00000005986	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Telomere maintenance 2.	0.943
ATR	ATM	ENSCANP00000035545	ENSCANP00000015871	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.998
ATR	FANCM	ENSCANP00000035545	ENSCANP00000012257	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	FA complementation group M.	0.990
ATR	MTOR	ENSCANP00000035545	ENSCANP00000021964	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.448
ATR	TELO2	ENSCANP00000035545	ENSCANP00000005986	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	Telomere maintenance 2.	0.983
FANCM	ATM	ENSCANP00000012257	ENSCANP00000015871	FA complementation group M.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.780
FANCM	ATR	ENSCANP00000012257	ENSCANP00000035545	FA complementation group M.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.990
FANCM	TELO2	ENSCANP00000012257	ENSCANP00000005986	FA complementation group M.	Telomere maintenance 2.	0.990
MTOR	ATM	ENSCANP00000021964	ENSCANP00000015871	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.630
MTOR	ATR	ENSCANP00000021964	ENSCANP00000035545	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.448
MTOR	RUVBL1	ENSCANP00000021964	ENSCANP00000039040	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.849
MTOR	RUVBL2	ENSCANP00000021964	ENSCANP00000007518	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.833
MTOR	TELO2	ENSCANP00000021964	ENSCANP00000005986	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	Telomere maintenance 2.	0.995
MTOR	TTI1	ENSCANP00000021964	ENSCANP00000039738	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	TELO2 interacting protein 1.	0.997
PRKDC	ATM	ENSCANP00000015005	ENSCANP00000015871	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.827