TFPI protein (Colobus angolensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TFPI

Tissue factor pathway inhibitor. (304 aa)

Predicted Functional Partners:

F10

0.952

F7

0.940

F3

0.767

F9

0.708

F2

0.691

PROZ

0.682

LOC105511210

0.674

PRSS1

0.674

LOC105511214

0.674

LOC105511217

0.674

Your Current Organism:

Colobus angolensis

NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
F10	F2	ENSCANP00000002888	ENSCANP00000033509	Coagulation factor X.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.986
F10	F3	ENSCANP00000002888	ENSCANP00000001459	Coagulation factor X.	Coagulation factor III, tissue factor.	0.928
F10	F7	ENSCANP00000002888	ENSCANP00000029981	Coagulation factor X.	Coagulation factor VII.	0.940
F10	F9	ENSCANP00000002888	ENSCANP00000006614	Coagulation factor X.	Coagulation factor IX.	0.860
F10	TFPI	ENSCANP00000002888	ENSCANP00000022471	Coagulation factor X.	Tissue factor pathway inhibitor.	0.952
F2	F10	ENSCANP00000033509	ENSCANP00000002888	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor X.	0.986
F2	F3	ENSCANP00000033509	ENSCANP00000001459	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor III, tissue factor.	0.728
F2	F7	ENSCANP00000033509	ENSCANP00000029981	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor VII.	0.865
F2	F9	ENSCANP00000033509	ENSCANP00000006614	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Coagulation factor IX.	0.871
F2	PROZ	ENSCANP00000033509	ENSCANP00000026820	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Protein Z, vitamin K dependent plasma glycoprotein; Belongs to the peptidase S1 family.	0.797
F2	TFPI	ENSCANP00000033509	ENSCANP00000022471	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Tissue factor pathway inhibitor.	0.691
F3	F10	ENSCANP00000001459	ENSCANP00000002888	Coagulation factor III, tissue factor.	Coagulation factor X.	0.928
F3	F2	ENSCANP00000001459	ENSCANP00000033509	Coagulation factor III, tissue factor.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.728
F3	F7	ENSCANP00000001459	ENSCANP00000029981	Coagulation factor III, tissue factor.	Coagulation factor VII.	0.995
F3	F9	ENSCANP00000001459	ENSCANP00000006614	Coagulation factor III, tissue factor.	Coagulation factor IX.	0.922
F3	PROZ	ENSCANP00000001459	ENSCANP00000026820	Coagulation factor III, tissue factor.	Protein Z, vitamin K dependent plasma glycoprotein; Belongs to the peptidase S1 family.	0.819
F3	TFPI	ENSCANP00000001459	ENSCANP00000022471	Coagulation factor III, tissue factor.	Tissue factor pathway inhibitor.	0.767
F7	F10	ENSCANP00000029981	ENSCANP00000002888	Coagulation factor VII.	Coagulation factor X.	0.940
F7	F2	ENSCANP00000029981	ENSCANP00000033509	Coagulation factor VII.	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	0.865
F7	F3	ENSCANP00000029981	ENSCANP00000001459	Coagulation factor VII.	Coagulation factor III, tissue factor.	0.995