OEF98864.1 protein (Vulcanibacillus modesticaldus)

Nodes:

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

OEF98864.1

Hypothetical protein; ATP-dependent DNA helicase. (1092 aa)

Predicted Functional Partners:

OEF98863.1

0.999

OEG00105.1

0.736

OEF96949.1

0.723

OEF99792.1

0.714

OEF96915.1

0.712

OEG00028.1

0.710

OEF98068.1

0.699

OEF99718.1

0.693

OEF98838.1

0.683

OEF99814.1

0.664

Your Current Organism:

Vulcanibacillus modesticaldus

NCBI taxonomy Id: 337097
Other names: Bacillus sp. BR, DSM 14931, JCM 12998, V. modesticaldus, strain Br

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OEF96915.1	OEF96949.1	BHF71_04090	BHF71_04260	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.568
OEF96915.1	OEF98068.1	BHF71_04090	BHF71_03345	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.438
OEF96915.1	OEF98838.1	BHF71_04090	BHF71_10765	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	TIGR02391 family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.487
OEF96915.1	OEF98863.1	BHF71_04090	BHF71_02750	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; ATP-dependent DNA helicase; Belongs to the helicase family. UvrD subfamily.	0.654
OEF96915.1	OEF98864.1	BHF71_04090	BHF71_02755	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; ATP-dependent DNA helicase.	0.712
OEF96915.1	OEF99718.1	BHF71_04090	BHF71_07780	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.673
OEF96915.1	OEF99792.1	BHF71_04090	BHF71_01045	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.697
OEF96915.1	OEF99814.1	BHF71_04090	BHF71_01160	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.432
OEF96915.1	OEG00028.1	BHF71_04090	BHF71_06610	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.650
OEF96915.1	OEG00105.1	BHF71_04090	BHF71_06155	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.726
OEF96949.1	OEF96915.1	BHF71_04260	BHF71_04090	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.568
OEF96949.1	OEF98068.1	BHF71_04260	BHF71_03345	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.584
OEF96949.1	OEF98838.1	BHF71_04260	BHF71_10765	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	TIGR02391 family protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.595
OEF96949.1	OEF98863.1	BHF71_04260	BHF71_02750	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; ATP-dependent DNA helicase; Belongs to the helicase family. UvrD subfamily.	0.605
OEF96949.1	OEF98864.1	BHF71_04260	BHF71_02755	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; ATP-dependent DNA helicase.	0.723
OEF96949.1	OEF99718.1	BHF71_04260	BHF71_07780	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.639
OEF96949.1	OEF99792.1	BHF71_04260	BHF71_01045	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.731
OEF96949.1	OEF99814.1	BHF71_04260	BHF71_01160	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.602
OEF96949.1	OEG00028.1	BHF71_04260	BHF71_06610	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.666
OEF96949.1	OEG00105.1	BHF71_04260	BHF71_06155	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.771

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

13

average node degree:

2.36

avg. local clustering coefficient:

0.855

expected number of edges:

11

PPI enrichment p-value:

0.263

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006352

DNA-templated transcription, initiation

5 of 25

1.83

2.2

1.35e-05

GO:0006281

DNA repair

4 of 60

1.35

1.15

0.0011

GO:0034654

Nucleobase-containing compound biosynthetic process

6 of 152

1.13

1.07

0.00024

GO:0090304

Nucleic acid metabolic process

9 of 316

0.98

1.02

1.35e-05

GO:0009059

Macromolecule biosynthetic process

6 of 256

0.9

0.73

0.0015

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016987

Sigma factor activity

5 of 25

1.83

2.3

7.03e-06

GO:0003700

DNA-binding transcription factor activity

6 of 75

1.43

1.72

1.22e-05

GO:0003677

DNA binding

7 of 267

0.95

0.84

0.00045

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5222

Oxoglutarate/iron-dependent dioxygenase, and methylated-DNA-[protein]-cysteine S-methyltransferase activity

3 of 5

2.31

1.63

0.00086

CL:5180

Mixed, incl. LysR, substrate-binding, and Pirin

4 of 35

1.59

1.29

0.0013

CL:2233

Mixed, incl. Sigma-70 factor, region 1.2, and Smr domain

2 of 6

2.05

0.78

0.0357

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

5 of 47

1.56

1.72

5.40e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0731

Sigma factor

4 of 23

1.77

1.88

7.09e-05

KW-0238

DNA-binding

7 of 150

1.2

1.36

1.20e-05

KW-0805

Transcription regulation

5 of 104

1.21

1.1

0.00053

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04545

Sigma-70, region 4

5 of 10

2.23

3.41

1.19e-07

PF00140

Sigma-70 factor, region 1.2

3 of 3

2.53

2.15

9.92e-05

PF04542

Sigma-70 region 2

4 of 20

1.83

1.87

9.92e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR007630

RNA polymerase sigma-70 region 4

5 of 6

2.45

3.76

4.83e-08

IPR000943

RNA polymerase sigma-70

5 of 6

2.45

3.76

4.83e-08

IPR014284

RNA polymerase sigma-70 like domain

5 of 22

1.89

2.51

2.75e-06

IPR013324

RNA polymerase sigma factor, region 3/4-like

5 of 22

1.89

2.51

2.75e-06

IPR009042

RNA polymerase sigma-70 region 1.2

3 of 3

2.53

2.15

0.00010

(more ...)

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