node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHL12980.1 | SHL13007.1 | SAMN05444398_101687 | SAMN05444398_101688 | GMP synthase (glutamine-hydrolysing). | L-glutamine synthetase. | 0.828 |
SHL12980.1 | SHL85670.1 | SAMN05444398_101687 | SAMN05444398_106149 | GMP synthase (glutamine-hydrolysing). | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.696 |
SHL12980.1 | SHL93947.1 | SAMN05444398_101687 | SAMN05444398_107167 | GMP synthase (glutamine-hydrolysing). | ATP diphosphatase. | 0.724 |
SHL12980.1 | apt | SAMN05444398_101687 | SAMN05444398_10519 | GMP synthase (glutamine-hydrolysing). | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.775 |
SHL12980.1 | gmk | SAMN05444398_101687 | SAMN05444398_10177 | GMP synthase (glutamine-hydrolysing). | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.734 |
SHL12980.1 | guaA | SAMN05444398_101687 | SAMN05444398_101105 | GMP synthase (glutamine-hydrolysing). | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.761 |
SHL12980.1 | guaB | SAMN05444398_101687 | SAMN05444398_101240 | GMP synthase (glutamine-hydrolysing). | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.936 |
SHL12980.1 | map | SAMN05444398_101687 | SAMN05444398_103221 | GMP synthase (glutamine-hydrolysing). | Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.754 |
SHL12980.1 | rplK | SAMN05444398_101687 | SAMN05444398_1239 | GMP synthase (glutamine-hydrolysing). | LSU ribosomal protein L11P; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | 0.701 |
SHL12980.1 | surE | SAMN05444398_101687 | SAMN05444398_101396 | GMP synthase (glutamine-hydrolysing). | 5'-nucleotidase /3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.764 |
SHL13007.1 | SHL12980.1 | SAMN05444398_101688 | SAMN05444398_101687 | L-glutamine synthetase. | GMP synthase (glutamine-hydrolysing). | 0.828 |
SHL13007.1 | guaA | SAMN05444398_101688 | SAMN05444398_101105 | L-glutamine synthetase. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.414 |
SHL85670.1 | SHL12980.1 | SAMN05444398_106149 | SAMN05444398_101687 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase (glutamine-hydrolysing). | 0.696 |
SHL85670.1 | SHL93947.1 | SAMN05444398_106149 | SAMN05444398_107167 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | ATP diphosphatase. | 0.431 |
SHL85670.1 | apt | SAMN05444398_106149 | SAMN05444398_10519 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.555 |
SHL85670.1 | gmk | SAMN05444398_106149 | SAMN05444398_10177 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.612 |
SHL85670.1 | guaA | SAMN05444398_106149 | SAMN05444398_101105 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP. | 0.976 |
SHL85670.1 | guaB | SAMN05444398_106149 | SAMN05444398_101240 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.953 |
SHL85670.1 | surE | SAMN05444398_106149 | SAMN05444398_101396 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 5'-nucleotidase /3'-nucleotidase; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.916 |
SHL93947.1 | SHL12980.1 | SAMN05444398_107167 | SAMN05444398_101687 | ATP diphosphatase. | GMP synthase (glutamine-hydrolysing). | 0.724 |