STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHM59904.1Uroporphyrinogen decarboxylase (URO-D); Belongs to the uroporphyrinogen decarboxylase family. (408 aa)    
Predicted Functional Partners:
SHM59876.1
Tetrahydromethanopterin S-methyltransferase subunit H.
 
  
 0.964
SHM59928.1
CmuA protein precursor; Belongs to the uroporphyrinogen decarboxylase family.
 
 
 0.941
SHK98574.1
uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
    
 0.837
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
  
  
 0.826
hemC
Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.795
SHL83666.1
Glutamate synthase (NADPH) large subunit.
    
 0.695
SHL91497.1
Coproporphyrinogen oxidase.
  
 0.583
SHL01687.1
5-methyltetrahydrofolate--homocysteine methyltransferase.
 
 
 0.564
SHM59849.1
Transcriptional regulator, TetR family.
    
  0.559
SHM59959.1
Putative regulatory protein, FmdB family.
       0.526
Your Current Organism:
Roseovarius pacificus
NCBI taxonomy Id: 337701
Other names: CGMCC 1.7083, DSM 29589, LMG 24575, LMG:24575, MCCC 1A00293, R. pacificus, Roseobacter sp. 812, Roseovarius pacificus Wang et al. 2009, strain 81-2
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