RN09_0091 protein (Mycobacterium tuberculosis variant africanum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

RN09_0091

Glutamine ABC transporter ATP-binding protein. (330 aa)

Predicted Functional Partners:

RN09_0090

0.999

RN09_3147

0.887

rpoB

0.686

RN09_0500

0.664

RN09_2045

0.664

RN09_2042

0.661

RN09_0537

0.642

dnaJ

0.641

rpoC

0.640

Pks6

0.637

Your Current Organism:

Mycobacterium tuberculosis variant africanum

NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Pks6	RN09_0091	RN09_0498	RN09_0091	Membrane bound polyketide synthase; Overlaps another CDS with the same product name.	Glutamine ABC transporter ATP-binding protein.	0.637
Pks6	RN09_0500	RN09_0498	RN09_0500	Membrane bound polyketide synthase; Overlaps another CDS with the same product name.	Membrane bound polyketide synthase.	0.989
Pks6	RN09_0537	RN09_0498	RN09_0537	Membrane bound polyketide synthase; Overlaps another CDS with the same product name.	ATPase; Belongs to the AAA ATPase family.	0.418
Pks6	RN09_2042	RN09_0498	RN09_2042	Membrane bound polyketide synthase; Overlaps another CDS with the same product name.	Polyketide synthase; Overlaps another CDS with the same product name.	0.998
Pks6	RN09_2045	RN09_0498	RN09_2045	Membrane bound polyketide synthase; Overlaps another CDS with the same product name.	Polyketide synthase; Overlaps another CDS with the same product name.	0.990
Pks6	dnaJ	RN09_0498	RN09_2916	Membrane bound polyketide synthase; Overlaps another CDS with the same product name.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.566
Pks6	rpoB	RN09_0498	RN09_0829	Membrane bound polyketide synthase; Overlaps another CDS with the same product name.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.631
Pks6	rpoC	RN09_0498	RN09_0830	Membrane bound polyketide synthase; Overlaps another CDS with the same product name.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.409
RN09_0090	RN09_0091	RN09_0090	RN09_0091	Glutamine ABC transporter permease.	Glutamine ABC transporter ATP-binding protein.	0.999
RN09_0091	Pks6	RN09_0091	RN09_0498	Glutamine ABC transporter ATP-binding protein.	Membrane bound polyketide synthase; Overlaps another CDS with the same product name.	0.637
RN09_0091	RN09_0090	RN09_0091	RN09_0090	Glutamine ABC transporter ATP-binding protein.	Glutamine ABC transporter permease.	0.999
RN09_0091	RN09_0500	RN09_0091	RN09_0500	Glutamine ABC transporter ATP-binding protein.	Membrane bound polyketide synthase.	0.664
RN09_0091	RN09_0537	RN09_0091	RN09_0537	Glutamine ABC transporter ATP-binding protein.	ATPase; Belongs to the AAA ATPase family.	0.642
RN09_0091	RN09_2042	RN09_0091	RN09_2042	Glutamine ABC transporter ATP-binding protein.	Polyketide synthase; Overlaps another CDS with the same product name.	0.661
RN09_0091	RN09_2045	RN09_0091	RN09_2045	Glutamine ABC transporter ATP-binding protein.	Polyketide synthase; Overlaps another CDS with the same product name.	0.664
RN09_0091	RN09_3147	RN09_0091	RN09_3147	Glutamine ABC transporter ATP-binding protein.	Glutamine ABC transporter permease.	0.887
RN09_0091	dnaJ	RN09_0091	RN09_2916	Glutamine ABC transporter ATP-binding protein.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.641
RN09_0091	rpoB	RN09_0091	RN09_0829	Glutamine ABC transporter ATP-binding protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.686
RN09_0091	rpoC	RN09_0091	RN09_0830	Glutamine ABC transporter ATP-binding protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.640
RN09_0500	Pks6	RN09_0500	RN09_0498	Membrane bound polyketide synthase.	Membrane bound polyketide synthase; Overlaps another CDS with the same product name.	0.989