Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
PtbBPhosphotyrosine protein phosphatase. (276 aa)    
Predicted Functional Partners:
FadE2
acyl-CoA dehydrogenase FadE2.
 
    0.903
NuoM
NADH-quinone oxidoreductase subunit M.
    
 
 0.835
PtpA
Protein-tyrosine-phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
      
 0.672
RN09_4021
Acid phosphatase.
      
 0.672
Cut2
Cutinase; Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle.
  
 
 0.598
Cut5
Putative cutinase.
  
 
 0.597
nuoB
NADH-quinone oxidoreductase subunit B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
    
   0.596
Cut3
Cutinase; Catalyzes the hydrolysis of cutin, a polyester that forms the structure of plant cuticle.
  
 
 0.596
Cut1
Cutinase.
  
 
 0.594
RN09_3976
Transmembrane carbonic anhydrase.
  
 
 0.580
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
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