Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (606 aa)    
Predicted Functional Partners:
Pca
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
   
 
 0.983
RN09_3014
2-oxoglutarate oxidoreductase subunit KorA.
   
 
 0.970
PykA
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 
 0.966
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
    
 0.943
CitA
Citrate synthase 2; Belongs to the citrate synthase family.
   
 
 0.936
PpdK
Pyruvate, phosphate dikinase PpdK.
     
 0.935
mqo
Malate:quinone oxidoreductase.
     
 0.935
GltA2
Citrate synthase 1; Belongs to the citrate synthase family.
   
 
 0.933
GltA1
Methylcitrate synthase PrpC; Belongs to the citrate synthase family.
   
 
 0.933
Eno
Enolase; Overlaps another CDS with the same product name.
     
 0.913
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
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