HspR protein (Mycobacterium tuberculosis variant africanum)

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Score

HspR

Heat shock protein transcriptional repressor HspR. (126 aa)

Predicted Functional Partners:

dnaK

0.992

dnaJ1

0.990

grpE

0.987

dnaJ

0.880

clpB

0.790

hrcA

0.711

GlnA2

0.625

sigA

0.604

SigB

0.604

GlnA3

0.578

Your Current Organism:

Mycobacterium tuberculosis variant africanum

NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GlnA2	GlnA3	RN09_2734	RN09_2317	Glutamine synthetase.	Glutamine synthetase GlnA.	0.854
GlnA2	HspR	RN09_2734	RN09_0433	Glutamine synthetase.	Heat shock protein transcriptional repressor HspR.	0.625
GlnA3	GlnA2	RN09_2317	RN09_2734	Glutamine synthetase GlnA.	Glutamine synthetase.	0.854
GlnA3	HspR	RN09_2317	RN09_0433	Glutamine synthetase GlnA.	Heat shock protein transcriptional repressor HspR.	0.578
HspR	GlnA2	RN09_0433	RN09_2734	Heat shock protein transcriptional repressor HspR.	Glutamine synthetase.	0.625
HspR	GlnA3	RN09_0433	RN09_2317	Heat shock protein transcriptional repressor HspR.	Glutamine synthetase GlnA.	0.578
HspR	SigB	RN09_0433	RN09_3300	Heat shock protein transcriptional repressor HspR.	RNA polymerase sigma factor SigB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.604
HspR	clpB	RN09_0433	RN09_0471	Heat shock protein transcriptional repressor HspR.	Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	0.790
HspR	dnaJ	RN09_0433	RN09_2916	Heat shock protein transcriptional repressor HspR.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.880
HspR	dnaJ1	RN09_0433	RN09_0432	Heat shock protein transcriptional repressor HspR.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.990
HspR	dnaK	RN09_0433	RN09_0430	Heat shock protein transcriptional repressor HspR.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.992
HspR	grpE	RN09_0433	RN09_0431	Heat shock protein transcriptional repressor HspR.	Protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]	0.987
HspR	hrcA	RN09_0433	RN09_2917	Heat shock protein transcriptional repressor HspR.	Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.711
HspR	sigA	RN09_0433	RN09_3293	Heat shock protein transcriptional repressor HspR.	RNA polymerase sigma factor SigA; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.	0.604
SigB	HspR	RN09_3300	RN09_0433	RNA polymerase sigma factor SigB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	Heat shock protein transcriptional repressor HspR.	0.604
SigB	clpB	RN09_3300	RN09_0471	RNA polymerase sigma factor SigB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family.	0.410
SigB	dnaJ	RN09_3300	RN09_2916	RNA polymerase sigma factor SigB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.475
SigB	dnaJ1	RN09_3300	RN09_0432	RNA polymerase sigma factor SigB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.469
SigB	dnaK	RN09_3300	RN09_0430	RNA polymerase sigma factor SigB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.506
SigB	hrcA	RN09_3300	RN09_2917	RNA polymerase sigma factor SigB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.	0.412