Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
UfaA1Cyclopropane-fatty-acyl-phospholipid synthase UfaA. (427 aa)    
Predicted Functional Partners:
RN09_0553
Hypothetical protein.
  
 0.997
RN09_0552
Hypothetical protein.
  
 0.992
RN09_0550
Transmembrane protein.
 
     0.938
SigK
ECF RNA polymerase sigma factor SigK; Belongs to the sigma-70 factor family. ECF subfamily.
     
 0.894
rskA
anti-sigma-K factor RskA; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the [...]
       0.756
DipZ
Integral membrane C-type cytochrome biogenesis protein DipZ.
     
 0.718
SigC
ECF RNA polymerase sigma factor SigC; Belongs to the sigma-70 factor family. ECF subfamily.
      
 0.660
SigH
ECF RNA polymerase sigma factor SigH; Belongs to the sigma-70 factor family. ECF subfamily.
      
 0.659
RN09_4693
Transcriptional regulator.
  
    0.561
RN09_3866
Transcriptional regulator.
   
    0.552
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
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