Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HemBDelta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (329 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 0.999
HemD
uroporphyrin-III C-methyltransferase.
 
 
 0.997
HemL
Glutamate-1-semialdehyde 2,1-aminomutase.
 
 
 0.996
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.981
CysG
Multifunctional uroporphyrin-III C-methyltransferase/precorrin-2 oxidase/ferrochelatase.
 
  
 0.950
RN09_0629
Transmembrane protein; Overlaps another CDS with the same product name.
  
    0.879
HemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 
 0.871
RN09_3263
Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family.
 
 
 0.768
RN09_0316
Transcriptional regulator.
  
 
 0.761
RN09_0630
Transmembrane protein; Overlaps another CDS with the same product name.
       0.746
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
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