Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RN09_0782Exonuclease V subunit beta RecB; Overlaps another CDS with the same product name; Belongs to the helicase family. UvrD subfamily. (426 aa)    
Predicted Functional Partners:
RecB
Exonuclease V subunit beta RecB; Overlaps another CDS with the same product name.
     0.994
recC
Exonuclease V subunit gamma RecC; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair [...]
 
 
 0.988
RecD
Exonuclease V subunit alpha RecD; Overlaps another CDS with the same product name.
 
 
 0.916
RN09_0778
Exonuclease V subunit alpha RecD; Overlaps another CDS with the same product name.
 
 
 0.914
RN09_2837
Hypothetical protein.
  
 
 0.597
DnaB
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily.
 
   
 0.541
RN09_2693
Hypothetical protein.
 
  
 0.529
RN09_3328
Recombinase A.
  
 
 0.522
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.522
RN09_1996
DNA polymerase I; Overlaps another CDS with the same product name.
 
   
 0.495
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
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