EchA3 protein (Mycobacterium tuberculosis variant africanum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

EchA3

enoyl-CoA hydratase EchA3. (231 aa)

Predicted Functional Partners:

RN09_0785

0.803

RN09_3100

0.760

RN09_3101

0.760

Fas

0.760

RN09_2305

0.742

sucC

0.721

Ltp4

0.719

RN09_0786

0.717

FadA2

0.716

FadA

0.716

Your Current Organism:

Mycobacterium tuberculosis variant africanum

NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EchA3	FadA	RN09_0784	RN09_1054	enoyl-CoA hydratase EchA3.	Acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.716
EchA3	FadA2	RN09_0784	RN09_0299	enoyl-CoA hydratase EchA3.	acetyl-CoA acetyltransferase FadA; Belongs to the thiolase-like superfamily. Thiolase family.	0.716
EchA3	Fas	RN09_0784	RN09_3102	enoyl-CoA hydratase EchA3.	Fatty acid synthase; Overlaps another CDS with the same product name.	0.760
EchA3	Ltp4	RN09_0784	RN09_4318	enoyl-CoA hydratase EchA3.	Lipid transfer protein.	0.719
EchA3	RN09_0785	RN09_0784	RN09_0785	enoyl-CoA hydratase EchA3.	Hypothetical protein.	0.803
EchA3	RN09_0786	RN09_0784	RN09_0786	enoyl-CoA hydratase EchA3.	Glyoxalase II.	0.717
EchA3	RN09_2305	RN09_0784	RN09_2305	enoyl-CoA hydratase EchA3.	Hypothetical protein.	0.742
EchA3	RN09_3100	RN09_0784	RN09_3100	enoyl-CoA hydratase EchA3.	Fatty acid synthase; Overlaps another CDS with the same product name.	0.760
EchA3	RN09_3101	RN09_0784	RN09_3101	enoyl-CoA hydratase EchA3.	Fatty acid synthase; Overlaps another CDS with the same product name.	0.760
EchA3	sucC	RN09_0784	RN09_1160	enoyl-CoA hydratase EchA3.	succinyl-CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.721
FadA	EchA3	RN09_1054	RN09_0784	Acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	enoyl-CoA hydratase EchA3.	0.716
FadA	FadA2	RN09_1054	RN09_0299	Acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	acetyl-CoA acetyltransferase FadA; Belongs to the thiolase-like superfamily. Thiolase family.	0.923
FadA	Fas	RN09_1054	RN09_3102	Acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Fatty acid synthase; Overlaps another CDS with the same product name.	0.677
FadA	RN09_2305	RN09_1054	RN09_2305	Acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Hypothetical protein.	0.902
FadA	RN09_3100	RN09_1054	RN09_3100	Acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Fatty acid synthase; Overlaps another CDS with the same product name.	0.677
FadA	RN09_3101	RN09_1054	RN09_3101	Acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	Fatty acid synthase; Overlaps another CDS with the same product name.	0.677
FadA	sucC	RN09_1054	RN09_1160	Acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	succinyl-CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.881
FadA2	EchA3	RN09_0299	RN09_0784	acetyl-CoA acetyltransferase FadA; Belongs to the thiolase-like superfamily. Thiolase family.	enoyl-CoA hydratase EchA3.	0.716
FadA2	FadA	RN09_0299	RN09_1054	acetyl-CoA acetyltransferase FadA; Belongs to the thiolase-like superfamily. Thiolase family.	Acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.923
FadA2	Fas	RN09_0299	RN09_3102	acetyl-CoA acetyltransferase FadA; Belongs to the thiolase-like superfamily. Thiolase family.	Fatty acid synthase; Overlaps another CDS with the same product name.	0.677