STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FrdCFumarate reductase membrane anchor subunit; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane; Belongs to the FrdC family. (126 aa)    
Predicted Functional Partners:
FrdD
Fumarate reductase membrane anchor subunit.
  
 0.999
SdhB
Succinate dehydrogenase iron-sulfur protein subunit.
  
 0.992
FrdA
Fumarate reductase flavoprotein subunit; Overlaps another CDS with the same product name.
 
 0.989
RN09_0304
Succinate dehydrogenase flavoprotein subunit.
  
 0.966
SdhA
Succinate dehydrogenase flavoprotein subunit; Overlaps another CDS with the same product name.
  
 0.966
SdhD
Succinate dehydrogenase hydrophobic membrane anchor subunit.
     
 0.913
SdhC
Succinate dehydrogenase cytochrome B-556 subunit; Overlaps another CDS with the same product name.
     
 0.911
fumC
Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
     
 0.908
sucC
succinyl-CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
     
 0.906
GabD1
Succinate-semialdehyde dehydrogenase.
     
  0.900
Your Current Organism:
Mycobacterium tuberculosis variant africanum
NCBI taxonomy Id: 33894
Other names: ATCC 25420, CIP 105147, M. tuberculosis variant africanum, Mycobacterium africanum
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